Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract

Daniela Bassi, Silvia Pizzi, Cinzia Azzoni, Lorena Bottarelli, Massimo Milione, Cesare Bordi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

65 Citazioni (Scopus)

Abstract

The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).
Lingua originaleEnglish
pagine (da-a)1273-1282
Numero di pagine10
RivistaCancer
Volume98
DOI
Stato di pubblicazionePubblicato - 2003

Keywords

  • Acid Anhydride Hydrolases
  • Adult
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms
  • Cyclin-Dependent Kinase Inhibitor p16
  • Endocrine Gland Neoplasms
  • Female
  • Gastrointestinal Neoplasms
  • Humans
  • Immunohistochemistry
  • Loss of Heterozygosity
  • Male
  • Middle Aged
  • Multiple Endocrine Neoplasia Type 1
  • Neoplasm Proteins
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53

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