Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract

Silvia Pizzi; Cinzia Azzoni; Daniela Bassi; Lorena Bottarelli; Massimo Milione; Cesare Bordi

doi:10.1002/cncr.11621

Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract

Silvia Pizzi, Cinzia Azzoni, Daniela Bassi, Lorena Bottarelli, Massimo Milione, Cesare Bordi

University of Parma

Risultato della ricerca: Contributo in rivista › Articolo in rivista

65 Citazioni (Scopus)

Abstract

The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).

Lingua originale	English
pagine (da-a)	1273-1282
Numero di pagine	10
Rivista	Cancer
Volume	98
DOI	https://doi.org/10.1002/cncr.11621
Stato di pubblicazione	Pubblicato - 2003

Keywords

Acid Anhydride Hydrolases
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Cyclin-Dependent Kinase Inhibitor p16
Endocrine Gland Neoplasms
Female
Gastrointestinal Neoplasms
Humans
Immunohistochemistry
Loss of Heterozygosity
Male
Middle Aged
Multiple Endocrine Neoplasia Type 1
Neoplasm Proteins
Retinoblastoma Protein
Tumor Suppressor Protein p53

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10.1002/cncr.11621

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title = "Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract",

abstract = "The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).",

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author = "Silvia Pizzi and Cinzia Azzoni and Daniela Bassi and Lorena Bottarelli and Massimo Milione and Cesare Bordi",

year = "2003",

doi = "10.1002/cncr.11621",

language = "English",

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pages = "1273--1282",

journal = "Cancer",

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TY - JOUR

T1 - Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract

AU - Pizzi, Silvia

AU - Azzoni, Cinzia

AU - Bassi, Daniela

AU - Bottarelli, Lorena

AU - Milione, Massimo

AU - Bordi, Cesare

PY - 2003

Y1 - 2003

N2 - The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).

AB - The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).

KW - Acid Anhydride Hydrolases

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colorectal Neoplasms

KW - Cyclin-Dependent Kinase Inhibitor p16

KW - Endocrine Gland Neoplasms

KW - Female

KW - Gastrointestinal Neoplasms

KW - Humans

KW - Immunohistochemistry

KW - Loss of Heterozygosity

KW - Male

KW - Middle Aged

KW - Multiple Endocrine Neoplasia Type 1

KW - Neoplasm Proteins

KW - Retinoblastoma Protein

KW - Tumor Suppressor Protein p53

KW - Acid Anhydride Hydrolases

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colorectal Neoplasms

KW - Cyclin-Dependent Kinase Inhibitor p16

KW - Endocrine Gland Neoplasms

KW - Female

KW - Gastrointestinal Neoplasms

KW - Humans

KW - Immunohistochemistry

KW - Loss of Heterozygosity

KW - Male

KW - Middle Aged

KW - Multiple Endocrine Neoplasia Type 1

KW - Neoplasm Proteins

KW - Retinoblastoma Protein

KW - Tumor Suppressor Protein p53

UR - http://hdl.handle.net/10807/61460

U2 - 10.1002/cncr.11621

DO - 10.1002/cncr.11621

M3 - Article

SN - 0008-543X

VL - 98

SP - 1273

EP - 1282

JO - Cancer

JF - Cancer

ER -

Genetic alterations in poorly differentiated endocrine carcinomas of the gastrointestinal tract

Abstract

Keywords

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