Generic antiretrovirals for the treatment of HIV: A novel challenge for Western countries?

Roberto Cauda, Dario Cattaneo, Massimo Andreoni, Gianpiero Carosi, Adriano Lazzarin, Giuliano Rizzardini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

The introduction of generic antiretroviral medications in developing countries has resulted in significant CD4 cell restoration, HIV viral decline, and a noteworthy reduction in the time to initiation of therapy. Projection models have also predicted significant cost saving associated with the extensive diffusion of generic antiretrovirals in developed countries. However, some uncertainties on generics have recently been raised. These concerns mainly relate to the adequacy of the study design for bioequivalence testing, the potential for uncontrolled switching from one generic to another, and the loss of adherence if patients switched from fixed-dose coformulations to single components in order to incorporate the new generic drugs. In the present review, we deal with current evidence and potential controversial issues regarding generic antiretrovirals and their underlying economic implications and provide some proposals on how to favor the widespread diffusion of generics in HIV medicine. This may be particularly relevant considering that the safe, systematic switch from patented to generic antiretrovirals could potentially guarantee access to therapies for HIV-infected patients worldwide and lead to money savings that would compensate the expenditure increase resulting from new, innovative HIV drugs.
Lingua originaleEnglish
pagine (da-a)381-393
Numero di pagine13
RivistaInternational Journal of Clinical Pharmacology and Therapeutics
Volume55
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Anti-HIV Agents
  • Bioequivalence
  • Clinical studies
  • Cost Savings
  • Cost-Benefit Analysis
  • Developing Countries
  • Drug Combinations
  • Drug Costs
  • Drug Substitution
  • Drugs, Generic
  • Generics
  • HIV
  • HIV Infections
  • Health Services Accessibility
  • Humans
  • Medication Adherence
  • Pharmacology
  • Pharmacology (medical)
  • Therapeutic Equivalency
  • Treatment Outcome

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