Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation

Nathalie Saulnier; Maria Ausiliatrice Puglisi; Wanda Lattanzi; L Castellini; Giovambattista Pani; Giuseppe Leone; Sergio Alfieri; Fabrizio Michetti; Ac Piscaglia; Antonio Gasbarrini

doi:10.3109/14653249.2010.515576

Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation

Nathalie Saulnier, Maria Ausiliatrice Puglisi, Wanda Lattanzi, L Castellini, Giovambattista Pani, Giuseppe Leone, Sergio Alfieri, Fabrizio Michetti, Ac Piscaglia, Antonio Gasbarrini

Risultato della ricerca: Contributo in rivista › Articolo in rivista

31 Citazioni (Scopus)

Abstract

Bone marrow- and adipose tissue-derived mesenchymal stromal cells (MSC) represent promising sources for regenerative medicine. However, the precise molecular mechanisms underlying MSC stemness maintenance versus differentiation are not fully understood. The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core.

Lingua originale	English
pagine (da-a)	329-340
Numero di pagine	12
Rivista	Cytotherapy
Volume	13
DOI	https://doi.org/10.3109/14653249.2010.515576
Stato di pubblicazione	Pubblicato - 2011

Keywords

Adipose Tissue
Adult
Binding Sites
Bone Marrow Cells
Cell Differentiation
Cell Lineage
Chromatin Immunoprecipitation
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Knockdown Techniques
Humans
Kruppel-Like Transcription Factors
Male
Mesenchymal Stem Cells
Middle Aged
Models, Biological
Polymerase Chain Reaction
Promoter Regions, Genetic
Protein Binding
Reproducibility of Results
Stromal Cells
Young Adult

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10.3109/14653249.2010.515576

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abstract = "Bone marrow- and adipose tissue-derived mesenchymal stromal cells (MSC) represent promising sources for regenerative medicine. However, the precise molecular mechanisms underlying MSC stemness maintenance versus differentiation are not fully understood. The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core.",

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AU - Saulnier, Nathalie

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AU - Lattanzi, Wanda

AU - Castellini, L

AU - Pani, Giovambattista

AU - Leone, Giuseppe

AU - Alfieri, Sergio

AU - Michetti, Fabrizio

AU - Piscaglia, Ac

AU - Gasbarrini, Antonio

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AB - Bone marrow- and adipose tissue-derived mesenchymal stromal cells (MSC) represent promising sources for regenerative medicine. However, the precise molecular mechanisms underlying MSC stemness maintenance versus differentiation are not fully understood. The aim of this study was to compare the genome-wide expression profiles of bone marrow-and adipose tissue-derived MSC, in order to identify a common molecular stemness core.

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KW - Bone Marrow Cells

KW - Cell Differentiation

KW - Cell Lineage

KW - Chromatin Immunoprecipitation

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KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Gene Knockdown Techniques

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KW - Reproducibility of Results

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ER -

Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation

Abstract

Keywords

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