Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Isabella Palumbo; Simonetta Piattoni; Vincenzo Valentini; Valeria Marini; Paola Contavalli; Monica Calzuola; Fabio Maria Vecchio; Debora Cecchini; Franca Falzetti; Cynthia Aristei

doi:10.1007/s00384-013-1754-1

Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Isabella Palumbo
, Simonetta Piattoni
, Vincenzo Valentini
, Valeria Marini
, Paola Contavalli
, Monica Calzuola
, Fabio Maria Vecchio
, Debora Cecchini
, Franca Falzetti
, Cynthia Aristei

University of Perugia

Risultato della ricerca: Contributo in rivista › Articolo

10 Citazioni (Scopus)

Abstract

In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

Lingua originale	Inglese
pagine (da-a)	31-41
Numero di pagine	11
Rivista	International Journal of Colorectal Disease
Volume	29
DOI	https://doi.org/10.1007/s00384-013-1754-1
Stato di pubblicazione	Pubblicato - 2014

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Keywords

Antineoplastic Combined Chemotherapy Protocols
Cell Line, Tumor
Chemoradiotherapy
Colorectal Neoplasms
Combined Modality Therapy
Fluorouracil
Humans
Quinazolines
Real-Time Polymerase Chain Reaction

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10.1007/s00384-013-1754-1

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title = "Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line",

abstract = "In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.",

keywords = "Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Chemoradiotherapy, Colorectal Neoplasms, Combined Modality Therapy, Fluorouracil, Humans, Quinazolines, Real-Time Polymerase Chain Reaction, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Chemoradiotherapy, Colorectal Neoplasms, Combined Modality Therapy, Fluorouracil, Humans, Quinazolines, Real-Time Polymerase Chain Reaction",

author = "Isabella Palumbo and Simonetta Piattoni and Vincenzo Valentini and Valeria Marini and Paola Contavalli and Monica Calzuola and Vecchio, \{Fabio Maria\} and Debora Cecchini and Franca Falzetti and Cynthia Aristei",

year = "2014",

doi = "10.1007/s00384-013-1754-1",

language = "English",

volume = "29",

pages = "31--41",

journal = "International Journal of Colorectal Disease",

issn = "0179-1958",

publisher = "Springer Nature",

}

TY - JOUR

T1 - Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

AU - Palumbo, Isabella

AU - Piattoni, Simonetta

AU - Valentini, Vincenzo

AU - Marini, Valeria

AU - Contavalli, Paola

AU - Calzuola, Monica

AU - Vecchio, Fabio Maria

AU - Cecchini, Debora

AU - Falzetti, Franca

AU - Aristei, Cynthia

PY - 2014

Y1 - 2014

N2 - In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

AB - In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Cell Line, Tumor

KW - Chemoradiotherapy

KW - Colorectal Neoplasms

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Humans

KW - Quinazolines

KW - Real-Time Polymerase Chain Reaction

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Cell Line, Tumor

KW - Chemoradiotherapy

KW - Colorectal Neoplasms

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Humans

KW - Quinazolines

KW - Real-Time Polymerase Chain Reaction

UR - http://hdl.handle.net/10807/63822

U2 - 10.1007/s00384-013-1754-1

DO - 10.1007/s00384-013-1754-1

M3 - Article

SN - 0179-1958

VL - 29

SP - 31

EP - 41

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

ER -

Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Abstract

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Keywords

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