In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.
- Antineoplastic Combined Chemotherapy Protocols
- Cell Line, Tumor
- Colorectal Neoplasms
- Combined Modality Therapy
- Real-Time Polymerase Chain Reaction