Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Isabella Palumbo; Simonetta Piattoni; Vincenzo Valentini; Valeria Marini; Paola Contavalli; Monica Calzuola; Fabio Maria Vecchio; Debora Cecchini; Franca Falzetti; Cynthia Aristei

doi:10.1007/s00384-013-1754-1

Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Isabella Palumbo, Simonetta Piattoni, Vincenzo Valentini, Valeria Marini, Paola Contavalli, Monica Calzuola, Fabio Maria Vecchio, Debora Cecchini, Franca Falzetti, Cynthia Aristei

University of Perugia

Risultato della ricerca: Contributo in rivista › Articolo in rivista

10 Citazioni (Scopus)

Abstract

In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

Lingua originale	English
pagine (da-a)	31-41
Numero di pagine	11
Rivista	International Journal of Colorectal Disease
Volume	29
DOI	https://doi.org/10.1007/s00384-013-1754-1
Stato di pubblicazione	Pubblicato - 2014

Keywords

Antineoplastic Combined Chemotherapy Protocols
Cell Line, Tumor
Chemoradiotherapy
Colorectal Neoplasms
Combined Modality Therapy
Fluorouracil
Humans
Quinazolines
Real-Time Polymerase Chain Reaction

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title = "Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line",

abstract = "In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.",

keywords = "Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Chemoradiotherapy, Colorectal Neoplasms, Combined Modality Therapy, Fluorouracil, Humans, Quinazolines, Real-Time Polymerase Chain Reaction, Antineoplastic Combined Chemotherapy Protocols, Cell Line, Tumor, Chemoradiotherapy, Colorectal Neoplasms, Combined Modality Therapy, Fluorouracil, Humans, Quinazolines, Real-Time Polymerase Chain Reaction",

author = "Isabella Palumbo and Simonetta Piattoni and Vincenzo Valentini and Valeria Marini and Paola Contavalli and Monica Calzuola and Vecchio, {Fabio Maria} and Debora Cecchini and Franca Falzetti and Cynthia Aristei",

year = "2014",

doi = "10.1007/s00384-013-1754-1",

language = "English",

volume = "29",

pages = "31--41",

journal = "International Journal of Colorectal Disease",

issn = "0179-1958",

publisher = "Springer Nature",

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TY - JOUR

T1 - Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

AU - Palumbo, Isabella

AU - Piattoni, Simonetta

AU - Valentini, Vincenzo

AU - Marini, Valeria

AU - Contavalli, Paola

AU - Calzuola, Monica

AU - Vecchio, Fabio Maria

AU - Cecchini, Debora

AU - Falzetti, Franca

AU - Aristei, Cynthia

PY - 2014

Y1 - 2014

N2 - In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

AB - In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Cell Line, Tumor

KW - Chemoradiotherapy

KW - Colorectal Neoplasms

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Humans

KW - Quinazolines

KW - Real-Time Polymerase Chain Reaction

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Cell Line, Tumor

KW - Chemoradiotherapy

KW - Colorectal Neoplasms

KW - Combined Modality Therapy

KW - Fluorouracil

KW - Humans

KW - Quinazolines

KW - Real-Time Polymerase Chain Reaction

UR - http://hdl.handle.net/10807/63822

U2 - 10.1007/s00384-013-1754-1

DO - 10.1007/s00384-013-1754-1

M3 - Article

SN - 0179-1958

VL - 29

SP - 31

EP - 41

JO - International Journal of Colorectal Disease

JF - International Journal of Colorectal Disease

ER -

Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Abstract

Keywords

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