Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Vincenzo Valentini, Fabio Maria Vecchio, Isabella Palumbo, Simonetta Piattoni, Valeria Marini, Paola Contavalli, Monica Calzuola, Debora Cecchini, Franca Falzetti, Cynthia Aristei

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.
Lingua originaleEnglish
pagine (da-a)31-41
Numero di pagine11
RivistaInternational Journal of Colorectal Disease
Volume29
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Cell Line, Tumor
  • Chemoradiotherapy
  • Colorectal Neoplasms
  • Combined Modality Therapy
  • Fluorouracil
  • Humans
  • Quinazolines
  • Real-Time Polymerase Chain Reaction

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