GC-MS and GC-MS/MS in PCI Mode Determination of Mescaline in Peyote Tea and in Biological Matrices

C Gambelunghe, Remo Marsili, K Aroni, M Bacci, Riccardo Rossi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)


Peyote, a cactus containing the hallucinogen mescaline, is used to induce altered states of consciousness in religious ceremonies or for recreational purpose. This study reports a case of an underage boy suspected of mescaline abuse. For this purpose, we analyzed a dark green liquid sample found in the bedroom of the boy whose urine and hair samples were collected shortly after the drink was found. A method by gas chromatography-mass spectrometry tandem mass spectrometry (GC-MS/MS) in positive chemical ionization mode was developed and validated in terms of linearity, specificity, accuracy, and sensitivity for mescaline determination at the low concentrations present in hair. GC-MS analysis of the liquid identified mescaline, while urine was negative; GC-MS/MS segmental hair analysis identified mescaline in the proximal segment (root to 2 cm), while the distal segments were negative. Although peyote was uncommonly encountered, its use was confirmed by segmental hair analysis that can provide long-term information about drugs use.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Forensic Sciences
Stato di pubblicazionePubblicato - 2012


  • Forensic science
  • GC-MS/MS
  • Hair analysis
  • Hallucinogens
  • Mescaline
  • Peyote


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