(gc) Direct visualization of intestinal villi by high-resolution magnifying upper endoscopy: a validation study

Giovanni Cammarota, Rossella Cianci, Giuseppe Zuccala', Veronica Ojetti, Massimo Montalto, Antonio Gasbarrini, Giovanni Battista Gasbarrini, Antonio Martino, Filippo Cremonini, Fabio Maria Vecchio, Giuseppe A. Pirozzi, Lucio Cuoco, Fabio M. Vecchio, Giovanni Gasbarrini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

66 Citazioni (Scopus)

Abstract

Abstract BACKGROUND: New generation videoendoscopes potentially may visualize duodenal villi. This study compared endoscopic findings with this type of instrument to the histopathologic evaluation of duodenal villi. METHODS: A total of 191 patients underwent upper endoscopy for the purpose of obtaining duodenal biopsy specimens. The findings were assessed independently by 3 experienced observers by using a commercially available, high-resolution, high-magnifying (x2) videoendoscope. The duodenal villous profile was determined by endoscopic magnification and by endoscopic magnification after filling the duodenum with water. With both endoscopic magnification and endoscopic magnification after filling the duodenum with water, villous patterns were scored as the following: definitely present, partially present, or definitely absent. Villous patterns also were histopathologically scored as the following: normal, partial villous pattern, or total villous atrophy. RESULTS: Interobserver variability was excellent (kappa = 0.93). The concordance between either endoscopic magnification or endoscopic magnification after filling the duodenum with water and histology was 100% for presence/absence of villi. The sensitivity, the specificity, and the positive and negative predictive values of endoscopic magnification for detection of any villous abnormality were 95%, 99%, 95%, and 99%, respectively; the respective values of endoscopic magnification after filling the duodenum with water were 95%, 98%, 92%, and 99%. CONCLUSIONS: High-resolution magnifying upper endoscopy can reliably predict the presence or the absence of duodenal villi.
Lingua originaleEnglish
pagine (da-a)732-738
Numero di pagine7
RivistaGastrointestinal Endoscopy
Stato di pubblicazionePubblicato - 2004

Keywords

  • intestinal villi

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