Gastrointestinal Uses of Botulinum Toxin

Maria Cariati, Maria Michela Chiarello, Marco Cannistra’, Maria Antonietta Lerose, Giuseppe Brisinda*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in libroChapter


Botulinum toxin (BT), one of the most powerful inhibitors that prevents the release of acetylcholine from nerve endings, represents an alternative therapeutic approach for “spastic” disorders of the gastrointestinal tract such as achalasia, gastroparesis, sphincter of Oddi dysfunction, chronic anal fissures, and pelvic floor dyssynergia. BT has proven to be safe and this allows it to be a valid alternative in patients at high risk of invasive procedures but long-term efficacy in many disorders has not been observed, primarily due to its relatively short duration of action. Administration of BT has a low rate of adverse reactions and complications. However, not all patients respond to BT therapy, and large randomized controlled trials are lacking for many conditions commonly treated with BT. The local injection of BT in some conditions becomes a useful tool to decide to switch to more invasive therapies. Since 1980, the toxin has rapidly transformed from lethal poison to a safe therapeutic agent, with a significant impact on the quality of life.
Lingua originaleEnglish
Titolo della pubblicazione ospiteBotulinum toxin therapy
EditorM. Hallett (eds.) S. M. Whitcup
Numero di pagine42
Stato di pubblicazionePubblicato - 2021


  • Achalasia
  • Autonomic nervous system diseases
  • Biliary diseases
  • Botulinum toxin
  • Cholinergic nerve ending
  • Enteric nervous system
  • Esophageal diseases
  • Fissures
  • Gastric emptying
  • Hirschsprung
  • Motility
  • Neuromuscular agents
  • Obesity
  • Spasm
  • Therapeutic agents


Entra nei temi di ricerca di 'Gastrointestinal Uses of Botulinum Toxin'. Insieme formano una fingerprint unica.

Cita questo