Gastroesophageal reflux after peroral endoscopic myotomy: A multicenter case-control study

Pietro Familiari, Guido Costamagna, Vivek Kumbhari, Niels Christian Bjerregaard, Mathieu Pioche, Edward Jones, Weon Jin Ko, Bu Hayee, Saowanee Ngamruengphong, Francois Mion, Ruben Hernaez, Sabine Roman, Alan H. Tieu, Mohamad El Zein, Tokunbo Ajayi, Amyn Haji, Joo Young Cho, Jeffrey Hazey, Kyle A. Perry, Thierry PonchonRastislav Kunda, Mouen A. Khashab

Risultato della ricerca: Contributo in rivistaArticolo in rivista

81 Citazioni (Scopus)

Abstract

Background and study aims The variables associated with gastroesophageal reflux (GER) after peroral endoscopic myotomy (POEM) are largely unknown. This study aimed to: 1) identify the prevalence of reflux esophagitis and asymptomatic GER in patients who underwent POEM, and 2) evaluate patient and intraprocedural variables associated with post-POEM GER. Patients and methods All patients who underwent POEM and subsequent objective testing for GER (pH study with or without upper gastrointestinal [GI] endoscopy) at seven tertiary academic centers (one Asian, two US, four European) were included. Patients were divided into two groups: 1) DeMeester score ≥ 14.72 (cases) and 2) DeMeester score of < 14.72 (controls). Asymptomatic GER was defined as a patient with a DeMeester score ≥ 14.72 who was not consuming proton pump inhibitor (PPI). Results A total of 282 patients (female 48.2, Caucasian 84.8; mean body mass index 24.1 kg/m 2) were included. Clinical success was achieved in 94.3 of patients. GER evaluation was completed after a median follow-up of 12 months (interquartile range 10 - 24 months). A DeMeester score of ≥ 14.72 was seen in 57.8 of patients. Multivariable analysis revealed female sex to be the only independent association (odds ratio 1.69, 95 confidence interval 1.04 - 2.74) with post-POEM GER. No intraprocedural variables were associated with GER. Upper GI endoscopy was available in 233 patients, 54 (23.2) of whom were noted to have reflux esophagitis (majority Los Angeles Grade A or B). GER was asymptomatic in 60.1. Conclusion Post-POEM GER was seen in the majority of patients. No intraprocedural variables were identified to allow for potential alteration in procedural technique.
Lingua originaleEnglish
pagine (da-a)634-642
Numero di pagine9
RivistaEndoscopy
Volume49
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Adult
  • Aged
  • Asia
  • Asymptomatic Diseases
  • Case-Control Studies
  • Endoscopy, Gastrointestinal
  • Esophageal Achalasia
  • Esophageal Sphincter, Lower
  • Esophagitis, Peptic
  • Europe
  • Female
  • Follow-Up Studies
  • Gastroesophageal Reflux
  • Humans
  • Male
  • Middle Aged
  • Myotomy
  • Postoperative Complications
  • Prevalence
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • United States

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