Gastric bypass and banding equally improve insulin sensitivity and β cell function

Caterina Conte, D Bradley, B Mittendorfer, Jc Eagon, Je Varela, E Fabbrini, A Gastaldelli, Kt Chambers, X Su, A Okunade, Bw Patterson, S. Klein

Risultato della ricerca: Contributo in rivistaArticolo in rivista

174 Citazioni (Scopus)

Abstract

Bariatric surgery in obese patients is a highly effective method of preventing or resolving type 2 diabetes mellitus (T2DM); however, the remission rate is not the same among different surgical procedures. We compared the effects of 20% weight loss induced by laparoscopic adjustable gastric banding (LAGB) or Roux-en-Y gastric bypass (RYGB) surgery on the metabolic response to a mixed meal, insulin sensitivity, and β cell function in nondiabetic obese adults. The metabolic response to meal ingestion was markedly different after RYGB than after LAGB surgery, manifested by rapid delivery of ingested glucose into the systemic circulation, by an increase in the dynamic insulin secretion rate, and by large, early postprandial increases in plasma glucose, insulin, and glucagon-like peptide-1 concentrations in the RYGB group. However, the improvement in oral glucose tolerance, insulin sensitivity, and overall β cell function after weight loss were not different between surgical groups. Additionally, both surgical procedures resulted in a similar decrease in adipose tissue markers of inflammation. We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults.
Lingua originaleEnglish
pagine (da-a)4667-4674
Numero di pagine8
RivistaTHE JOURNAL OF CLINICAL INVESTIGATION
Volume122
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Adult
  • Antigens, CD11b
  • Area Under Curve
  • Body Composition
  • Ceramides
  • Cytokines
  • Diglycerides
  • Female
  • Gastric Bypass
  • Gastroplasty
  • Humans
  • Inflammation Mediators
  • Insulin
  • Insulin Resistance
  • Insulin-Secreting Cells
  • Intra-Abdominal Fat
  • Male
  • Membrane Glycoproteins
  • Middle Aged
  • Mucins
  • Muscle, Skeletal
  • Obesity
  • Organ Size
  • Postprandial Period
  • Receptors, G-Protein-Coupled
  • Weight Loss

Fingerprint Entra nei temi di ricerca di 'Gastric bypass and banding equally improve insulin sensitivity and β cell function'. Insieme formano una fingerprint unica.

Cita questo