Galanin increases potassium evoked release of [3H]5-hydroxytryptamine from rat hypothalamic synaptosomal preparations

Maria Martire, Paolo Preziosi, K Fuxe, Lf Agnati, G Pistritto

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

10 Citazioni (Scopus)

Abstract

The effects of galanin (GAL) have been evaluated on the depolarization evoked release of [3H]5-HT (serotonin or 5-hydroxytryptamine) from rat hypothalamic synaptosomal preparations, using low concentrations of potassium (15 mM). In the same preparation effects of GAL were also evaluated on [3H]5-HT uptake, using kinetic analysis to determine effects on Vmax values and Km values. GAL concentrations of 0.1-10 nM caused a concentration-related increase of the depolarization-evoked release of [3H]5-HT without influencing [3H]5-HT uptake. The results indicate the existence of high affinity GAL receptors on the hypothalamic 5-HT nerve terminals, exerting a facilitatory influence on depolarization-evoked [3H]5-HT release.
Lingua originaleEnglish
pagine (da-a)87-90
Numero di pagine4
RivistaNeuroscience Letters
Volume122
Stato di pubblicazionePubblicato - 1991

Keywords

  • Animals
  • Galanin
  • Hypothalamus
  • Kinetics
  • Male
  • Peptides
  • Potassium
  • Rats
  • Rats, Inbred Strains
  • Serotonin
  • Synaptosomes

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