Fungicidal activity of the human peptide hepcidin 20 alone or in combination with other antifungals against Candida glabrata isolates

Maurizio Sanguinetti, Arianna Tavanti, Giuseppantonio Maisetta, Gaetano Del Gaudio, Raffaele Petruzzelli, Giovanna Batoni, Sonia Senesi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

31 Citazioni (Scopus)

Abstract

Candida glabrata infections are often difficult to eradicate due to the intrinsically low susceptibility to azoles of this species. In addition, C. glabrata has also been shown to be insensitive to several cationic peptides, which have been shown to be promising novel therapeutic candidates for the treatment of fungal infection. In this study, the in vitro fungicidal activity of the human cationic peptide hepcidin 20 (Hep-20) was evaluated against clinical isolates of C. glabrata with different levels of fluconazole susceptibility. Interestingly, all isolates were susceptible to Hep-20 (100-200 μg/ml) at pH 7.4, whereas the fungicidal effect of the peptide was higher (50 μg/ml) at acidic pH values. In addition, an increased antifungal activity was observed for Hep-20 with amphotericin B and a synergistic effect was demonstrated for the Hep-20/fluconazole and Hep-20/caspofungin combinations.
Lingua originaleEnglish
pagine (da-a)2484-2487
Numero di pagine4
RivistaPEPTIDES
Volume32
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Acids
  • Amphotericin B
  • Antifungal Agents
  • Antimicrobial Cationic Peptides
  • Candida glabrata
  • Drug Synergism
  • Echinocandins
  • Fluconazole
  • Humans
  • Hydrogen-Ion Concentration
  • Microbial Sensitivity Tests
  • Peptide Fragments

Fingerprint

Entra nei temi di ricerca di 'Fungicidal activity of the human peptide hepcidin 20 alone or in combination with other antifungals against Candida glabrata isolates'. Insieme formano una fingerprint unica.

Cita questo