Fungal infections after liver transplantation: incidence and outcome

Gabriele Sganga, Salvatore Agnes, Giuseppe Bianco, Francesco Frongillo, Maria Carmen Lirosi, Erida Nure

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Fungal infections, although less frequent than bacterial infections, represent a severe comorbidity with an exponential increase in mortality rate in liver transplantation patients. The incidence of invasive fungal infections (IFIs) after solid organ transplantation ranges from 7% to 42%, with Candida spp. and Aspergillus spp. as the most common pathogens. Fungal infections in liver transplant recipients have been associated with poor outcome and mortality rates ranging from 65% to 90% for invasive aspergillosis and 30% to 50% for invasive candidiasis. The results largely depend on early diagnosis and early initiation of specific treatment for IFIs. Therefore, the diagnosis must be prompt, preferably based on microbiological data, both cultures and biomarkers, and/or based on clinical features and known risk factors.
Lingua originaleEnglish
pagine (da-a)2314-2318
Numero di pagine5
RivistaTransplantation Proceedings
Volume46
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • liver transplantation

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