TY - JOUR
T1 - Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report
AU - Marangoni, D
AU - Falsini, B
AU - Piccardi, M
AU - Ambrosio, L
AU - Minnella, Angelo Maria
AU - Savastano, Maria Cristina
AU - Bisti, S
AU - Maccarone, R
AU - Fadda, A
AU - Mello, E
AU - Concolino, P
AU - Capoluongo, E.
PY - 2013
Y1 - 2013
N2 - BACKGROUND:\r\nTo determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.\r\nMETHODS:\r\nThirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.\r\nRESULTS:\r\nAfter three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.\r\nCONCLUSIONS:\r\nThe present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
AB - BACKGROUND:\r\nTo determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.\r\nMETHODS:\r\nThirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.\r\nRESULTS:\r\nAfter three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.\r\nCONCLUSIONS:\r\nThe present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
KW - Age-related macular degeneration
KW - Electroretinography
KW - Gene polymorphism
KW - Saffron
KW - Age-related macular degeneration
KW - Electroretinography
KW - Gene polymorphism
KW - Saffron
UR - https://publicatt.unicatt.it/handle/10807/53660
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84884963753&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884963753&origin=inward
U2 - 10.1186/1479-5876-11-228
DO - 10.1186/1479-5876-11-228
M3 - Article
SN - 1479-5876
VL - 11
SP - 1
EP - 11
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
IS - 1
ER -