Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report

D Marangoni*, B Falsini, M Piccardi, L Ambrosio, Angelo Maria Minnella, Maria Cristina Savastano, S Bisti, R Maccarone, A Fadda, E Mello, P Concolino, E. Capoluongo

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

28 Citazioni (Scopus)

Abstract

BACKGROUND:\r\nTo determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.\r\nMETHODS:\r\nThirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6-12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.\r\nRESULTS:\r\nAfter three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.\r\nCONCLUSIONS:\r\nThe present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
Lingua originaleInglese
pagine (da-a)1---11
RivistaJournal of Translational Medicine
Volume11
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 2013

All Science Journal Classification (ASJC) codes

  • Biochimica, Genetica, Biologia Molecolare Generali

Keywords

  • Age-related macular degeneration
  • Electroretinography
  • Gene polymorphism
  • Saffron

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