TY - JOUR
T1 - Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report.
AU - Marangoni, Dario
AU - Falsini, Benedetto
AU - Piccardi, Marco
AU - Ambrosio, Lucia
AU - Minnella, Angelo Maria
AU - Savastano, Maria Cristina
AU - Bisti, Silvia
AU - Maccarone, Rita
AU - Fadda, Antonello
AU - Mello, Enrica
AU - Concolino, Paola
AU - Capoluongo, Ettore
PY - 2013
Y1 - 2013
N2 - Abstract
BACKGROUND:
To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.
METHODS:
Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6--12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18[degree sign]) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.
RESULTS:
After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.
CONCLUSIONS:
The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
AB - Abstract
BACKGROUND:
To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes.
METHODS:
Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6--12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18[degree sign]) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures.
RESULTS:
After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes.
CONCLUSIONS:
The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
KW - Age related maculopathy
KW - antioxidants
KW - electrophysiology
KW - genetics
KW - Age related maculopathy
KW - antioxidants
KW - electrophysiology
KW - genetics
UR - http://hdl.handle.net/10807/48491
U2 - 10.1186/1479-5876-11-228
DO - 10.1186/1479-5876-11-228
M3 - Article
SN - 1479-5876
VL - 2013
SP - 228-N/A
JO - Journal of Translational Medicine
JF - Journal of Translational Medicine
ER -