Functional connectivity MRI and post-operative language performance in temporal lobe epilepsy: initial experience

Cesare Colosimo, Carlo Sestieri, Gian Luca Romani, Massimo Caulo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)


Anterior temporal lobectomy is an effective treatment for drug-resistant epilepsy of temporal origin, although new language impairment may develop after surgery. Since correlations between functional connectivity (FC) MRI of the language network and verbal-IQ performance before surgery have recently been reported, we investigated the existence of correlations between the preoperative FC of the language network and post-operative verbal-IQ decline. FC between nodes of the language network of the two hemispheres (Interhemispheric-FC) and within nodes of the left hemisphere (LH-FC) and language lateralization indexes were estimated in five right-handed patients with non-tumoral left temporal lobe epilepsy undergoing anterior temporal lobectomy. Correlations between preoperative FC measures and lateralization indexes, and the post-operative (12 months) neuropsychological verbal-IQ decline were investigated. Verbal-IQ decline was inversely correlated with the degree of left lateralization and directly correlated with the strength of Interhemispheric-FC. No significant correlation was found between LH-FC and post-operative verbal-IQ change. The results from this limited number of patients suggest that a stronger preoperative connectivity between homologue regions, associated with the absence of a definite hemispheric lateralization, appears to be an unfavorable prognostic biomarker.
Lingua originaleEnglish
pagine (da-a)158-162
Numero di pagine5
Stato di pubblicazionePubblicato - 2014


  • Adolescent
  • Adult
  • Anterior Temporal Lobectomy
  • Brain Mapping
  • Epilepsy, Temporal Lobe
  • Female
  • Functional Laterality
  • Humans
  • Language
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Preoperative Care
  • Retrospective Studies
  • Young Adult
  • epilepsy
  • functional neuroimaging
  • language
  • magnetic resonance imaging
  • temporal lobe

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