Functional and molecular evidence of myelin- and neuroprotection by thyroid hormone administration in experimental allergic encephalomyelitis

Mauro Filippi, Paolo Maria Rossini, M. L. Dell'Acqua, L. Lorenzini, G. D'Intino, S. Sivilia, P. Pasqualetti, V. Panetta, M. Paradisi, M. M. Filippi, C. Baiguera, M. Pizzi, L. Giardino, L. Calzà

Risultato della ricerca: Contributo in rivistaArticolo in rivista

28 Citazioni (Scopus)

Abstract

Recent data in mouse and rat demyelination models indicate that administration of thyroid hormone (TH) has a positive effect on the demyelination/remyelination balance. As axonal pathology has been recognized as an early neuropathological event in multiple sclerosis, and remyelination is considered a pre-eminent neuroprotective strategy, in this study we investigated whether TH administration improves nerve impulse propagation and protects axons.
Lingua originaleEnglish
pagine (da-a)454-470
Numero di pagine17
RivistaNeuropathology and Applied Neurobiology
Volume38
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Animals
  • Axons
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Myelin Sheath
  • Neuroprotective Agents
  • Rats
  • Spinal Cord
  • Thyroid Hormones
  • Triiodothyronine

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