Abstract
Recent data in mouse and rat demyelination models indicate that administration of thyroid hormone (TH) has a positive effect on the demyelination/remyelination balance. As axonal pathology has been recognized as an early neuropathological event in multiple sclerosis, and remyelination is considered a pre-eminent neuroprotective strategy, in this study we investigated whether TH administration improves nerve impulse propagation and protects axons.
Lingua originale | English |
---|---|
pagine (da-a) | 454-470 |
Numero di pagine | 17 |
Rivista | Neuropathology and Applied Neurobiology |
Volume | 38 |
DOI | |
Stato di pubblicazione | Pubblicato - 2012 |
Keywords
- Animals
- Axons
- Disease Models, Animal
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Myelin Sheath
- Neuroprotective Agents
- Rats
- Spinal Cord
- Thyroid Hormones
- Triiodothyronine