Full-spectrum (FUSE) versus standard forward-viewing colonoscopy in an organised colorectal cancer screening programme

Cesare Hassan, Carlo Senore, Franco Radaelli, Giovanni De Pretis, Romano Sassatelli, Arrigo Arrigoni, Gianpiero Manes, Arnaldo Amato, Andrea Anderloni, Franco Armelao, Alessandra Mondardini, Cristiano Spada, Barbara Omazzi, Maurizio Cavina, Gianni Miori, Chiara Campanale, Giuliana Sereni, Nereo Segnan, Alessandro Repici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Objective Miss rate of polyps has been shown to be substantially lower with full-spectrum endoscopy (FUSE) compared with standard forward-viewing (SFV) colonoscopy in a tandem study at per polyp analysis. However, there is uncertainty on whether FUSE is also associated with a higher detection rate of colorectal neoplasia, especially advanced lesions, in per patient analysis. Methods Consecutive subjects undergoing colonoscopy following a positive faecal immunochemical test (FIT) by experienced endoscopists and performed in the context of a regional colorectal cancer population-screening programme were randomised between colonoscopy with either FUSE or SFV colonoscopy in seven Italian centres. Randomisation was stratified by gender, age group and screening history. Primary outcomes included detection rates of advanced adenomas (A-ADR), adenomas (ADR) and sessile-serrated polyps (SSPDR). Results Of 741 eligible subjects, 658 were randomised to either FUSE (n=328) or SFV (n=330) colonoscopy and included in the analysis. Overall, 293/658 and 143/658 subjects had at least one adenoma (ADR 44.5%) and advanced adenoma (A-ADR 21.7%), respectively, while SSP was the most advanced lesion in 18 cases (SSPDR 2.7%). ADR and A-ADR were 43.6% and 19.5% in the FUSE arm, and 45.5% and 23.9% in the SFV arm, with no difference for both ADR (OR for FUSE: 0.96, 95% CI 0.81 to 1.14) and A-ADR (OR for FUSE: 0.82, 95% CI 0.61 to 1.09). No difference in SSPDR or multiplicity was detected between the two arms. In the per polyp analysis, the mean number of adenomas and proximal adenomas per patient was 0.81±1.25 and 0.47±0.93 in the FUSE arm, and 0.85±1.33 and 0.48±0.96 in the SFV colonoscopy arm (p=NS for both comparisons). Conclusions No statistically significant difference in ADR and A-ADR between FUSE and SFV colonoscopy was detected in a per patient analysis in FIT-positive patients. Trial registration number ISRCTN10357435.
Lingua originaleEnglish
pagine (da-a)1949-1955
Numero di pagine7
RivistaGut
Volume66
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • COLONIC NEOPLASMS
  • COLONIC POLYPS
  • COLORECTAL CANCER SCREENING
  • COLORECTAL ADENOMAS
  • COLONOSCOPY

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