Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project

Ana Ferro, Ana Rute Costa, Samantha Morais, Paola Bertuccio, Matteo Rota, Claudio Pelucchi, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Domenico Palli, Monica Ferraroni, Guo-Pei Yu, Rossella Bonzi, Bárbara Peleteiro, Lizbeth López-Carrillo, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Reza Malekzadeh, David ZaridzeDmitry Maximovich, Jesus Vioque, Eva M. Navarrete-Muñoz, Juan Alguacil, Gemma Castaño-Vinyals, Alicja Wolk, Niclas Håkansson, Raúl Ulises Hernández-Ramírez, Mohammadreza Pakseresht, Mary H. Ward, Farhad Pourfarzi, Lina Mu, Malaquias López-Cervantes, Roberto Persiani, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Stefania Boccia, Eva Negri, Erica Negri, Maria Constanza Camargo, Maria Paula Curado, Carlo La Vecchia, Nuno Lunet, Nuno Miguel De Sousa Lunet

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.
Lingua originaleEnglish
pagine (da-a)3090-3101
Numero di pagine12
RivistaInternational Journal of Cancer
Stato di pubblicazionePubblicato - 2020


  • fruits
  • gastric cancer
  • nutrition
  • pooled analyses
  • vegetables


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