Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: Our experience

Maurizio Martini, Francesco Fanfani, Anna Fagotti, Giovanni Scambia, Gian Franco Zannoni, Angelo Piermattei, Frediano Inzani, Marianna Valente, Damiano Arciuolo, Valerio Gallotta

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Background: The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambiguous or inconclusive diagnosis by endometrial biopsies and imaging. Methods: A retrospective study was performed selecting patients who underwent surgery with IOE for suspected EC at our institution from 2012 to 2018. A K coefficient was determined with respect to the histotype, tumor grade, myometrial infiltration and cervical involvement. Results: Data analysis has been performed on 202 women. The IOE evaluation was distributed as Endometrioid (n = 180) and Non-Endometrioid (n = 22). The comparison between the frozen section (FS) and the definitive histological subtype showed an overall agreement rate of 93,07% (k = 0.612) and an agreement of 97.2% for Endometrioid vs 59% for Non-Endometrioid tumors. The FIGO system grading was the same in 91,1% of patients, none was upgraded and in 8,9% downgraded. Observed agreements were 89,11% and 95,54% for myometrial and cervical involvement, respectively. Conclusions: The good agreement between intraoperative grading, myometrial invasion and their histological definition on permanent sections highlights that FS is a good predictor for surgical outcome, in particular in presence of a preoperative ambiguous or inconclusive diagnostic evaluation.
Lingua originaleEnglish
pagine (da-a)1096-N/A
RivistaBMC Cancer
Volume19
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Biopsy
  • Endometrial Neoplasms
  • Endometrial carcinoma
  • Female
  • Frozen Sections
  • Frozen section
  • Humans
  • Intraoperative Care
  • Intraoperative surgical staging
  • Magnetic Resonance Imaging
  • Neoplasm Grading
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Preoperative Care
  • Retrospective Studies

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