Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Anna Rita Bentivoglio; R. Marconi; L. Grasso; A. Antonini; D. De Gaspari; P. Barone; G. Santangelo; C. Colosimo; G. Meco; T. P. Avarello; E. Bottacchi; A. Cannas; M. G. Ceravolo; R. Ceravolo; G. Cicarelli; R. M. Gaglio; L. Giglia; F. Iemolo; M. Manfredi; A. Nicoletti; M. Pederzoli; A. Petrone; A. Pisani; F. E. Pontieri; R. Quatrale; S. Ramat; R. Scala; G. Volpe; S. Zappulla; F. Stocchi; G. Trianni; P. Del Dotto; F. Morgante; L. Morgante; G. Fabbrini; Angelo Antonini; Paolo Barone; Carlo Colosimo; Roberto Marconi; Letterio Morgante; D. Benincasa; M. Sensi; M. Braga; M. Capecci; N. Caravona; G. D’Asta; F. A. De Falco; G. Pezzoli; M. Di Giovanni; G. Floris; S. Gallerini; G. Gurgone; D. Frosini; S. Meoni; R. Savica; V. Moschella; F. Pepe; V. Petretta; M. G. Randisi; M. Romeno; M. Picillo; V. Sorbello; D. Tiple; R. Muoio; V. Toni; C. Logi; S. Bartalini; M. Ulivelli; M. Perini; S. Lanfranchi; S. Griffini; B. Troianiello; M. Baratti; S. Amidei; D. Consoli; M. Iellamo; T. Cuomo; A. Scaglioni; D. Medici; G. Abbruzzese; G. Di Brigida; G. A. Cocco; V. Agnetti; G. Cossu; M. Deriu; M. Abrignani; C. Modica; G. Albani; L. Pradotto; P. Martinelli; C. Scaglione; M. Mucchiut; S. Zanini; F. Pennisi; P. Soliveri; A. Albanese; L. Bartolomei; R. L’Erario; L. Capus; L. Ferigo; R. Marano; V. Nastasi; R. Luciano; L. Maiello; P. Simone; D. Fogli; L. Lopiano; M. Pesare; G. Nordera; E. Pilleri; T. Scaravilli; E. Giaccaglini; C. Alesi; Tania Corbetta; Simona Sgarbi; Andrea Rapisarda; Sara Rizzoli; Luca Zanoli; Alessandra Manfredi

doi:10.1007/s10072-011-0807-x

Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Anna Rita Bentivoglio, R. Marconi, L. Grasso, A. Antonini, D. De Gaspari, P. Barone, G. Santangelo, C. Colosimo, G. Meco, T. P. Avarello, E. Bottacchi, A. Cannas, M. G. Ceravolo, R. Ceravolo, G. Cicarelli, R. M. Gaglio, L. Giglia, F. Iemolo, M. Manfredi, A. NicolettiM. Pederzoli, A. Petrone, A. Pisani, F. E. Pontieri, R. Quatrale, S. Ramat, R. Scala, G. Volpe, S. Zappulla, F. Stocchi, G. Trianni, P. Del Dotto, F. Morgante, L. Morgante, G. Fabbrini, Angelo Antonini, Paolo Barone, Carlo Colosimo, Roberto Marconi, Letterio Morgante, D. Benincasa, M. Sensi, M. Braga, M. Capecci, N. Caravona, G. D’Asta, F. A. De Falco, G. Pezzoli, M. Di Giovanni, G. Floris, S. Gallerini, G. Gurgone, D. Frosini, S. Meoni, R. Savica, V. Moschella, F. Pepe, V. Petretta, M. G. Randisi, M. Romeno, M. Picillo, V. Sorbello, D. Tiple, R. Muoio, V. Toni, C. Logi, S. Bartalini, M. Ulivelli, M. Perini, S. Lanfranchi, S. Griffini, B. Troianiello, M. Baratti, S. Amidei, D. Consoli, M. Iellamo, T. Cuomo, A. Scaglioni, D. Medici, G. Abbruzzese, G. Di Brigida, G. A. Cocco, V. Agnetti, G. Cossu, M. Deriu, M. Abrignani, C. Modica, G. Albani, L. Pradotto, P. Martinelli, C. Scaglione, M. Mucchiut, S. Zanini, F. Pennisi, P. Soliveri, A. Albanese, L. Bartolomei, R. L’Erario, L. Capus, L. Ferigo, R. Marano, V. Nastasi, R. Luciano, L. Maiello, P. Simone, D. Fogli, L. Lopiano, M. Pesare, G. Nordera, E. Pilleri, T. Scaravilli, E. Giaccaglini, C. Alesi, Tania Corbetta, Simona Sgarbi, Andrea Rapisarda, Sara Rizzoli, Luca Zanoli, Alessandra Manfredi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

15 Citazioni (Scopus)

Abstract

Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

Lingua originale	English
pagine (da-a)	585-593
Numero di pagine	9
Rivista	Neurological Sciences
Volume	33
DOI	https://doi.org/10.1007/s10072-011-0807-x
Stato di pubblicazione	Pubblicato - 2012

Keywords

Frontal functions
Parkinson and cognitive impairment

Accesso al documento

10.1007/s10072-011-0807-x

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Bentivoglio, A. R., Marconi, R., Grasso, L., Antonini, A., De Gaspari, D., Barone, P., Santangelo, G., Colosimo, C., Meco, G., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, M. G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, L., Iemolo, F., Manfredi, M., ... Manfredi, A. (2012). Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders. Neurological Sciences, 33, 585-593. https://doi.org/10.1007/s10072-011-0807-x

Bentivoglio, Anna Rita ; Marconi, R. ; Grasso, L. ; Antonini, A. ; De Gaspari, D. ; Barone, P. ; Santangelo, G. ; Colosimo, C. ; Meco, G. ; Avarello, T. P. ; Bottacchi, E. ; Cannas, A. ; Ceravolo, M. G. ; Ceravolo, R. ; Cicarelli, G. ; Gaglio, R. M. ; Giglia, L. ; Iemolo, F. ; Manfredi, M. ; Nicoletti, A. ; Pederzoli, M. ; Petrone, A. ; Pisani, A. ; Pontieri, F. E. ; Quatrale, R. ; Ramat, S. ; Scala, R. ; Volpe, G. ; Zappulla, S. ; Stocchi, F. ; Trianni, G. ; Del Dotto, P. ; Morgante, F. ; Morgante, L. ; Fabbrini, G. ; Antonini, Angelo ; Barone, Paolo ; Colosimo, Carlo ; Marconi, Roberto ; Morgante, Letterio ; Benincasa, D. ; Sensi, M. ; Braga, M. ; Capecci, M. ; Caravona, N. ; D’Asta, G. ; De Falco, F. A. ; Pezzoli, G. ; Di Giovanni, M. ; Floris, G. ; Gallerini, S. ; Gurgone, G. ; Frosini, D. ; Meoni, S. ; Savica, R. ; Moschella, V. ; Pepe, F. ; Petretta, V. ; Randisi, M. G. ; Romeno, M. ; Picillo, M. ; Sorbello, V. ; Tiple, D. ; Muoio, R. ; Toni, V. ; Logi, C. ; Bartalini, S. ; Ulivelli, M. ; Perini, M. ; Lanfranchi, S. ; Griffini, S. ; Troianiello, B. ; Baratti, M. ; Amidei, S. ; Consoli, D. ; Iellamo, M. ; Cuomo, T. ; Scaglioni, A. ; Medici, D. ; Abbruzzese, G. ; Di Brigida, G. ; Cocco, G. A. ; Agnetti, V. ; Cossu, G. ; Deriu, M. ; Abrignani, M. ; Modica, C. ; Albani, G. ; Pradotto, L. ; Martinelli, P. ; Scaglione, C. ; Mucchiut, M. ; Zanini, S. ; Pennisi, F. ; Soliveri, P. ; Albanese, A. ; Bartolomei, L. ; L’Erario, R. ; Capus, L. ; Ferigo, L. ; Marano, R. ; Nastasi, V. ; Luciano, R. ; Maiello, L. ; Simone, P. ; Fogli, D. ; Lopiano, L. ; Pesare, M. ; Nordera, G. ; Pilleri, E. ; Scaravilli, T. ; Giaccaglini, E. ; Alesi, C. ; Corbetta, Tania ; Sgarbi, Simona ; Rapisarda, Andrea ; Rizzoli, Sara ; Zanoli, Luca ; Manfredi, Alessandra. / Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders. In: Neurological Sciences. 2012 ; Vol. 33. pagg. 585-593.

@article{ab5c698e76ab4e52a5680b8a914bd933,

title = "Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders",

abstract = "Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.",

keywords = "Frontal functions, Parkinson and cognitive impairment, Frontal functions, Parkinson and cognitive impairment",

author = "Bentivoglio, {Anna Rita} and R. Marconi and L. Grasso and A. Antonini and {De Gaspari}, D. and P. Barone and G. Santangelo and C. Colosimo and G. Meco and Avarello, {T. P.} and E. Bottacchi and A. Cannas and Ceravolo, {M. G.} and R. Ceravolo and G. Cicarelli and Gaglio, {R. M.} and L. Giglia and F. Iemolo and M. Manfredi and A. Nicoletti and M. Pederzoli and A. Petrone and A. Pisani and Pontieri, {F. E.} and R. Quatrale and S. Ramat and R. Scala and G. Volpe and S. Zappulla and F. Stocchi and G. Trianni and {Del Dotto}, P. and F. Morgante and L. Morgante and G. Fabbrini and Angelo Antonini and Paolo Barone and Carlo Colosimo and Roberto Marconi and Letterio Morgante and D. Benincasa and M. Sensi and M. Braga and M. Capecci and N. Caravona and G. D{\textquoteright}Asta and {De Falco}, {F. A.} and G. Pezzoli and {Di Giovanni}, M. and G. Floris and S. Gallerini and G. Gurgone and D. Frosini and S. Meoni and R. Savica and V. Moschella and F. Pepe and V. Petretta and Randisi, {M. G.} and M. Romeno and M. Picillo and V. Sorbello and D. Tiple and R. Muoio and V. Toni and C. Logi and S. Bartalini and M. Ulivelli and M. Perini and S. Lanfranchi and S. Griffini and B. Troianiello and M. Baratti and S. Amidei and D. Consoli and M. Iellamo and T. Cuomo and A. Scaglioni and D. Medici and G. Abbruzzese and {Di Brigida}, G. and Cocco, {G. A.} and V. Agnetti and G. Cossu and M. Deriu and M. Abrignani and C. Modica and G. Albani and L. Pradotto and P. Martinelli and C. Scaglione and M. Mucchiut and S. Zanini and F. Pennisi and P. Soliveri and A. Albanese and L. Bartolomei and R. L{\textquoteright}Erario and L. Capus and L. Ferigo and R. Marano and V. Nastasi and R. Luciano and L. Maiello and P. Simone and D. Fogli and L. Lopiano and M. Pesare and G. Nordera and E. Pilleri and T. Scaravilli and E. Giaccaglini and C. Alesi and Tania Corbetta and Simona Sgarbi and Andrea Rapisarda and Sara Rizzoli and Luca Zanoli and Alessandra Manfredi",

year = "2012",

doi = "10.1007/s10072-011-0807-x",

language = "English",

volume = "33",

pages = "585--593",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia Srl:via Decembrio 28, 20137 Milan Italy:011 39 2 5425971, EMAIL: riccardi@springer.it, Fax: 011 39 2 55193360",

}

Bentivoglio, AR, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Barone, P, Santangelo, G, Colosimo, C, Meco, G, Avarello, TP, Bottacchi, E, Cannas, A, Ceravolo, MG, Ceravolo, R, Cicarelli, G, Gaglio, RM, Giglia, L, Iemolo, F, Manfredi, M, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, FE, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Stocchi, F, Trianni, G, Del Dotto, P, Morgante, F, Morgante, L, Fabbrini, G, Antonini, A, Barone, P, Colosimo, C, Marconi, R, Morgante, L, Benincasa, D, Sensi, M, Braga, M, Capecci, M, Caravona, N, D’Asta, G, De Falco, FA, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Gurgone, G, Frosini, D, Meoni, S, Savica, R, Moschella, V, Pepe, F, Petretta, V, Randisi, MG, Romeno, M, Picillo, M, Sorbello, V, Tiple, D, Muoio, R, Toni, V, Logi, C, Bartalini, S, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, G, Di Brigida, G, Cocco, GA, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Pradotto, L, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L’Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L & Manfredi, A 2012, 'Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders', Neurological Sciences, vol. 33, pagg. 585-593. https://doi.org/10.1007/s10072-011-0807-x

Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders. / Bentivoglio, Anna Rita; Marconi, R.; Grasso, L.; Antonini, A.; De Gaspari, D.; Barone, P.; Santangelo, G.; Colosimo, C.; Meco, G.; Avarello, T. P.; Bottacchi, E.; Cannas, A.; Ceravolo, M. G.; Ceravolo, R.; Cicarelli, G.; Gaglio, R. M.; Giglia, L.; Iemolo, F.; Manfredi, M.; Nicoletti, A.; Pederzoli, M.; Petrone, A.; Pisani, A.; Pontieri, F. E.; Quatrale, R.; Ramat, S.; Scala, R.; Volpe, G.; Zappulla, S.; Stocchi, F.; Trianni, G.; Del Dotto, P.; Morgante, F.; Morgante, L.; Fabbrini, G.; Antonini, Angelo; Barone, Paolo; Colosimo, Carlo; Marconi, Roberto; Morgante, Letterio; Benincasa, D.; Sensi, M.; Braga, M.; Capecci, M.; Caravona, N.; D’Asta, G.; De Falco, F. A.; Pezzoli, G.; Di Giovanni, M.; Floris, G.; Gallerini, S.; Gurgone, G.; Frosini, D.; Meoni, S.; Savica, R.; Moschella, V.; Pepe, F.; Petretta, V.; Randisi, M. G.; Romeno, M.; Picillo, M.; Sorbello, V.; Tiple, D.; Muoio, R.; Toni, V.; Logi, C.; Bartalini, S.; Ulivelli, M.; Perini, M.; Lanfranchi, S.; Griffini, S.; Troianiello, B.; Baratti, M.; Amidei, S.; Consoli, D.; Iellamo, M.; Cuomo, T.; Scaglioni, A.; Medici, D.; Abbruzzese, G.; Di Brigida, G.; Cocco, G. A.; Agnetti, V.; Cossu, G.; Deriu, M.; Abrignani, M.; Modica, C.; Albani, G.; Pradotto, L.; Martinelli, P.; Scaglione, C.; Mucchiut, M.; Zanini, S.; Pennisi, F.; Soliveri, P.; Albanese, A.; Bartolomei, L.; L’Erario, R.; Capus, L.; Ferigo, L.; Marano, R.; Nastasi, V.; Luciano, R.; Maiello, L.; Simone, P.; Fogli, D.; Lopiano, L.; Pesare, M.; Nordera, G.; Pilleri, E.; Scaravilli, T.; Giaccaglini, E.; Alesi, C.; Corbetta, Tania; Sgarbi, Simona; Rapisarda, Andrea; Rizzoli, Sara; Zanoli, Luca; Manfredi, Alessandra.

In: Neurological Sciences, Vol. 33, 2012, pag. 585-593.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

AU - Bentivoglio, Anna Rita

AU - Marconi, R.

AU - Grasso, L.

AU - Antonini, A.

AU - De Gaspari, D.

AU - Barone, P.

AU - Santangelo, G.

AU - Colosimo, C.

AU - Meco, G.

AU - Avarello, T. P.

AU - Bottacchi, E.

AU - Cannas, A.

AU - Ceravolo, M. G.

AU - Ceravolo, R.

AU - Cicarelli, G.

AU - Gaglio, R. M.

AU - Giglia, L.

AU - Iemolo, F.

AU - Manfredi, M.

AU - Nicoletti, A.

AU - Pederzoli, M.

AU - Petrone, A.

AU - Pisani, A.

AU - Pontieri, F. E.

AU - Quatrale, R.

AU - Ramat, S.

AU - Scala, R.

AU - Volpe, G.

AU - Zappulla, S.

AU - Stocchi, F.

AU - Trianni, G.

AU - Del Dotto, P.

AU - Morgante, F.

AU - Morgante, L.

AU - Fabbrini, G.

AU - Antonini, Angelo

AU - Barone, Paolo

AU - Colosimo, Carlo

AU - Marconi, Roberto

AU - Morgante, Letterio

AU - Benincasa, D.

AU - Sensi, M.

AU - Braga, M.

AU - Capecci, M.

AU - Caravona, N.

AU - D’Asta, G.

AU - De Falco, F. A.

AU - Pezzoli, G.

AU - Di Giovanni, M.

AU - Floris, G.

AU - Gallerini, S.

AU - Gurgone, G.

AU - Frosini, D.

AU - Meoni, S.

AU - Savica, R.

AU - Moschella, V.

AU - Pepe, F.

AU - Petretta, V.

AU - Randisi, M. G.

AU - Romeno, M.

AU - Picillo, M.

AU - Sorbello, V.

AU - Tiple, D.

AU - Muoio, R.

AU - Toni, V.

AU - Logi, C.

AU - Bartalini, S.

AU - Ulivelli, M.

AU - Perini, M.

AU - Lanfranchi, S.

AU - Griffini, S.

AU - Troianiello, B.

AU - Baratti, M.

AU - Amidei, S.

AU - Consoli, D.

AU - Iellamo, M.

AU - Cuomo, T.

AU - Scaglioni, A.

AU - Medici, D.

AU - Abbruzzese, G.

AU - Di Brigida, G.

AU - Cocco, G. A.

AU - Agnetti, V.

AU - Cossu, G.

AU - Deriu, M.

AU - Abrignani, M.

AU - Modica, C.

AU - Albani, G.

AU - Pradotto, L.

AU - Martinelli, P.

AU - Scaglione, C.

AU - Mucchiut, M.

AU - Zanini, S.

AU - Pennisi, F.

AU - Soliveri, P.

AU - Albanese, A.

AU - Bartolomei, L.

AU - L’Erario, R.

AU - Capus, L.

AU - Ferigo, L.

AU - Marano, R.

AU - Nastasi, V.

AU - Luciano, R.

AU - Maiello, L.

AU - Simone, P.

AU - Fogli, D.

AU - Lopiano, L.

AU - Pesare, M.

AU - Nordera, G.

AU - Pilleri, E.

AU - Scaravilli, T.

AU - Giaccaglini, E.

AU - Alesi, C.

AU - Corbetta, Tania

AU - Sgarbi, Simona

AU - Rapisarda, Andrea

AU - Rizzoli, Sara

AU - Zanoli, Luca

AU - Manfredi, Alessandra

PY - 2012

Y1 - 2012

N2 - Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

AB - Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

KW - Frontal functions

KW - Parkinson and cognitive impairment

KW - Frontal functions

KW - Parkinson and cognitive impairment

UR - http://hdl.handle.net/10807/28017

U2 - 10.1007/s10072-011-0807-x

DO - 10.1007/s10072-011-0807-x

M3 - Article

VL - 33

SP - 585

EP - 593

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

ER -

Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Abstract

Keywords

Accesso al documento

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