TY - JOUR
T1 - From Regular Catharsis with Castor Oil to Recognizing the Importance of the Intestinal Microbiota
AU - Settanni, Carlo Romano
AU - Ianiro, Gianluca
AU - Franceschi, Francesco
AU - Gasbarrini, Giovanni
AU - Gasbarrini, Antonio
PY - 2020
Y1 - 2020
N2 - The need to shed light on the unknown aspects of pathophysiology of common disorders, such as gastrointestinal ones, has led researchers through last decades to study and define the role of microorganisms within the human intestine and their interactions with the host. The progress of technology has permitted the overcoming of culture-based methods to study microbes and paved the way to molecular techniques, which allow the analysis of microbial genome, microbial functions, and metabolism. These progresses opened a window on the world of microbiology and permitted to deepen into the key role played by gut microbiota and dysbiosis in health status and diseases, both gastrointestinal and extraintestinal. So, scientists focused their attention in developing new strategies to restore eubiosis and to manipulate gut microbes by modifying dietary habits, administrating antibiotics, probiotics, and prebiotics and using fecal microbiota transplantation as treatment of gastrointestinal, infectious, cardiovascular, metabolic, immune-mediated, neuro-psychiatric, and oncological disorders. The next challenges will be to elaborate standard protocols with definite outcomes predictors in disease-specific settings.
AB - The need to shed light on the unknown aspects of pathophysiology of common disorders, such as gastrointestinal ones, has led researchers through last decades to study and define the role of microorganisms within the human intestine and their interactions with the host. The progress of technology has permitted the overcoming of culture-based methods to study microbes and paved the way to molecular techniques, which allow the analysis of microbial genome, microbial functions, and metabolism. These progresses opened a window on the world of microbiology and permitted to deepen into the key role played by gut microbiota and dysbiosis in health status and diseases, both gastrointestinal and extraintestinal. So, scientists focused their attention in developing new strategies to restore eubiosis and to manipulate gut microbes by modifying dietary habits, administrating antibiotics, probiotics, and prebiotics and using fecal microbiota transplantation as treatment of gastrointestinal, infectious, cardiovascular, metabolic, immune-mediated, neuro-psychiatric, and oncological disorders. The next challenges will be to elaborate standard protocols with definite outcomes predictors in disease-specific settings.
KW - Dysbiosis
KW - Fecal microbiota transplantation
KW - Microbiota
KW - Prebiotic
KW - Probiotic
KW - Dysbiosis
KW - Fecal microbiota transplantation
KW - Microbiota
KW - Prebiotic
KW - Probiotic
UR - https://publicatt.unicatt.it/handle/10807/151522
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85078800001&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85078800001&origin=inward
U2 - 10.1159/000505395
DO - 10.1159/000505395
M3 - Article
SN - 0257-2753
SP - 128
EP - 136
JO - Digestive Diseases
JF - Digestive Diseases
IS - January
ER -