From Mild Cognitive Impairment to Alzheimer's Disease: A New Perspective in the "land" of Human Brain Reactivity and Connectivity

Paolo Maria Rossini, Riccardo Di Iorio, Giuseppe Granata, Francesca Miraglia, Fabrizio Vecchio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

In a recent study, analyzing the modulation of γ-band oscillations, Naro and colleagues demonstrated that transcranial alternating current stimulation could drive the gamma rhythms in the human EEG in cognitive healthy elderly subjects but not in mild cognitive impairment (MCI) prodromal to Alzheimer's disease (AD) and in early AD patients. Therefore, this method is proposed to intercept early in the disease course those MCI subjects who are in a pre-symptomatic stage of an already established AD. This prediction index may help the clinician to adopt a better prevention/follow-up strategy. In this direction, the novel advances in EEG analysis for the evaluation of brain reactivity and connectivity-namely via innovative mathematical approach, i.e., graph theory-represent a promising tool for a non-invasive and easy-to-perform neurophysiological marker that could be used for the pre-symptomatic diagnosis of AD and to predict MCI progression to dementia.
Lingua originaleEnglish
pagine (da-a)1389-1393
Numero di pagine5
RivistaJournal of Alzheimer's Disease
Volume53
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Alzheimer's disease
  • Clinical Psychology
  • Effective connectivity
  • Electroencephalography
  • Functional connectivity
  • Geriatrics and Gerontology
  • Graph theory
  • Mild cognitive impairment
  • Non-invasive brain stimulation
  • Psychiatry and Mental Health

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