From growing to secreting: new roles for mTOR in aging cells

Risultato della ricerca: Contributo in rivistaArticolo in rivista

36 Citazioni (Scopus)

Abstract

Deregulation of the nutrient sensitive mTOR signaling pathway has been recently involved in several age-related diseases, and pharmacological blockade of mTOR extends longevity in model organisms and in mice. Mechanistic studies in vitro have shed light on the role of mTOR-dependent growth signals in promoting senescence and exhaustion of quiescent stem cells, thus linking excess nutrients to tissue ageing. Novel findings add complexity to this theoretical framework, revealing that mTOR cooperates with autophagy to promote the "secretory phenotype" of senescent cells and the release of factors known to contribute to defective renewal and dysfunction of aging tissues. Thus, both cell autonomous and cell non-autonomous mechanisms link unchecked mTOR activity to cell senescence and by extension to the aging process.
Lingua originaleEnglish
pagine (da-a)2450-2453
Numero di pagine4
RivistaCELL CYCLE
Volume10
Stato di pubblicazionePubblicato - 2011

Keywords

  • Animals
  • Autophagy
  • Cell Aging
  • Cytokines
  • Mice
  • Signal Transduction
  • Stem Cells
  • TOR Serine-Threonine Kinases

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