From Cell Architecture to Mitochondrial Signaling: Role of Intermediate Filaments in Health, Aging, and Disease

Emanuele Marzetti, Rosa Di Lorenzo, Riccardo Calvani, Vito Pesce, Francesco Landi, Hélio José Coelho-Júnior, Anna Picca

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

The coordination of cytoskeletal proteins shapes cell architectures and functions. Age-related changes in cellular mechanical properties have been linked to decreased cellular and tissue dysfunction. Studies have also found a relationship between mitochondrial function and the cytoskeleton. Cytoskeleton inhibitors impact mitochondrial quality and function, including motility and morphology, membrane potential, and respiration. The regulatory properties of the cytoskeleton on mitochondrial functions are involved in the pathogenesis of several diseases. Disassembly of the axon’s cytoskeleton and the release of neurofilament fragments have been documented during neurodegeneration. However, these changes can also be related to mitochondrial impairments, spanning from reduced mitochondrial quality to altered bioenergetics. Herein, we discuss recent research highlighting some of the pathophysiological roles of cytoskeleton disassembly in aging, neurodegeneration, and neuromuscular diseases, with a focus on studies that explored the relationship between intermediate filaments and mitochondrial signaling as relevant contributors to cellular health and disease.
Lingua originaleEnglish
pagine (da-a)1-21
Numero di pagine21
RivistaInternational Journal of Molecular Sciences
Volume26
DOI
Stato di pubblicazionePubblicato - 2025

Keywords

  • axonal transport
  • cell architecture
  • cell quality
  • cytoskeleton
  • vimentin
  • muscle aging
  • neurodegeneration
  • neurofilaments
  • sarcomere
  • mitochondrial quality

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