Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

The fasting concentration of free fatty acids (FFA) in the ascitic fluid was determined in 14 patients with malignant ascites and in 19 patients with liver cirrhosis. In malignant ascites FFA levels were increased more than three times when compared with the levels in cirrhotic ascites (5.241 +/- 0.493 vs. 1.558 +/- 0.170 mumol/ml; P < 0.0001). Palmitic acid was the most representative saturated FFA (which together accounted for 2.499 +/- 0.323 vs. 0.833 +/- 0.064 mumol/ml; P < 0.0001), while unsaturated FFA (2.741 +/- 0.298 vs. 0.725 +/- 0.111 mumol/ml; P < 0.001) were represented, in decreasing order, by oleic, linoleic and arachidonic acids. The ratio of unsaturated to saturated FFA was higher in neoplastic patients (1.35 +/- 0.29 vs. 0.826 +/- 0.065 P < 0.05). Albumin concentration in ascitic fluid of neoplastic patients was 22.44 +/- 1.35 g/l, while that of cirrhotic patients was 8.19 +/- 0.32 g/l, P < 0.0001. A close relationship (R2 = 95.14%) between albumin concentration in ascitic fluid and levels of total FFA was found. These data support the hypothesis that the elevation of FFA in ascitic fluid allows discrimination between malignant and non-malignant ascites.
Lingua originaleEnglish
pagine (da-a)13-22
Numero di pagine10
RivistaClinica Chimica Acta
Volume239
Stato di pubblicazionePubblicato - 1995

Keywords

  • Adult
  • Aged
  • Albumins
  • Arachidonic Acid
  • Ascitic Fluid
  • Carcinoma, Hepatocellular
  • Fatty Acids, Nonesterified
  • Female
  • Humans
  • Linoleic Acid
  • Linoleic Acids
  • Liver Cirrhosis
  • Liver Neoplasms
  • Male
  • Middle Aged
  • Oleic Acid
  • Oleic Acids
  • Palmitic Acid
  • Palmitic Acids
  • Peritoneal Neoplasms

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