Four doses of unpegylated versus one dose of pegylated filgrastim as supportive therapy in R-CHOP-14 for elderly patients with diffuse large B-cell lymphoma

Francesco D'Alo', Stefan Hohaus, Valentina Bozzoli, Maria Chiara Tisi, Elena Maiolo, Eleonora Alma, Silvia Bellesi, Maria Teresa Voso, Giuseppe Leone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

The primary objective of this prospective, randomized study was to compare the efficacy of a reduced regimen of only four doses of unpegylated filgrastim from day +8 to +11 per cycle with a standard once per cycle administration of pegylated filgrastim to maintain dose-intensity of R-CHOP-14 (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone given every 14 d) in previously untreated elderly patients with diffuse large B-cell lymphoma (DLBCL). We included 51 patients (median age 66 years, range 60-76). Median dose intensity did not differ between the group of 24 patients receiving four doses of unpegylated filgrastim of each cycle (87·5%) and the group of 27 patients receiving pegylated filgrastim once per cycle on day 2 (89·4%) (P = 0·9). There was also no difference in the frequency of adverse events, such as episodes of neutropenic fever and unplanned hospitalizations. Patient characteristics that negatively influenced dose intensity were reduced performance status, advanced stage disease and poor-risk International Prognostic Index, with Eastern Cooperative Oncology Group performance status ≥2 being the most significant factor. In conclusion, a limited support with 4 d of filgrastim appears to be equivalent to pegylated filgrastim administered once per cycle, and appears to be sufficient to maintain dose-intensity of the R-CHOP-14 regimen in elderly patients with DLBCL without risk factors.
Lingua originaleEnglish
pagine (da-a)787-794
Numero di pagine8
RivistaBritish Journal of Haematology
Volume169
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Age Factors
  • Aged
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Combined Chemotherapy Protocols
  • Comorbidity
  • Cyclophosphamide
  • Doxorubicin
  • Drug Administration Schedule
  • Female
  • Filgrastim
  • G-CSF
  • Granulocyte Colony-Stimulating Factor
  • Humans
  • Lymphoma, Large B-Cell, Diffuse
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prednisone
  • R-CHOP-14
  • Recombinant Proteins
  • Risk Factors
  • Treatment Outcome
  • Vincristine
  • diffuse large B-cell lymphoma
  • pegylated G-CSF

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