Forward-viewing echoendoscope versus standard echoendoscope for endoscopic ultrasound-guided tissue acquisition of solid lesions: A randomized, multicenter study

Guido Costamagna, Alberto Leonardo Larghi, Mostafa Ibrahim, Lorenzo Fuccio, Selma Lekkerkerker, Pierre Eisendrath, Leonardo Frazzoni, Paul Fockens, Marina La Marca, Jeanin E. Van Hooft, Jacques Deviere

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)

Abstract

Background A forward-viewing linear (FVL) echoendoscope has been developed with the aim of overcoming some of the limitations of standard curved linear-array (CLA) echoendoscopes. There are no existing studies comparing the performance of the two echoendoscopes for endoscopic ultrasound-guided tissue acquisition (EUS-TA) of solid lesions other than subepithelial lesions. Methods This was a prospective, multicenter, randomized trial with a noninferiority design comparing FVL vs. CLA echoendoscopes in patients with solid lesions of the gastrointestinal tract or adjacent organs. Primary outcomes were successful identification of the lesion and success of EUS-TA. Secondary outcomes were safety, sensitivity, specificity, and diagnostic accuracy of the two different scopes for EUS-TA. Results 126 patients with solid lesions were randomly assigned to the CLA group (63 patients) or the FVL group (63 patients). The two groups were homogeneous with no differences in terms of needle type used, mean number of passes, and site of EUS-TA. No differences were observed between the FVL vs. CLA scopes in identification of the lesion (96.8% vs. 98.4%; P >0.99) and technical success of EUS-TA (92.1% vs. 96.8%; P =0.44). No adverse events occurred. Overall, diagnostic accuracy (77.8% vs. 84.1%), sensitivity (76.6% vs. 84.1%), and specificity (81.3% vs. 84.2%) did not differ between the two groups. Conclusions Our results strongly suggest that the FVL echoendoscope is noninferior to the CLA scope for the detection and performance of EUS-TA in patients with solid lesions of the gastrointestinal tract and adjacent organs. In addition, the FVL scope has the same diagnostic yield, accuracy, and safety as the CLA scope.
Lingua originaleEnglish
pagine (da-a)444-451
Numero di pagine8
RivistaEndoscopy
Volume51
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Comparative Effectiveness Research
  • Diagnostic Errors
  • Digestive System Neoplasms
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration
  • Endosonography
  • Humans
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Treatment Outcome

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