Follow-up to Age 4 Years of Treatment of Type 1 Retinopathy of Prematurity Intravitreal Bevacizumab Injection versus Laser: Fluorescein Angiographic Findings

Domenico Lepore, Fernando Molle, Eugenio Maria Mercuri, Antonio Baldascino, Daniela Ricci, Graham E. Quinn

Risultato della ricerca: Contributo in rivistaArticolo in rivista

44 Citazioni (Scopus)

Abstract

Purpose: To compare structural outcome at age 4 years of eyes treated with intravitreal injection of bevacizumab with fellow eyes treated with conventional laser photoablation in type 1 retinopathy of prematurity (ROP). Design: Single, randomized, controlled trial. Participants: All inborn babies with type 1 zone 1 ROP at the Neonatal Intensive Care Unit of the Catholic University, Rome, from September 1, 2009, to March 31, 2012. Methods: In 21 infants (42 eyes), 1 eye was randomized to receive an intravitreal injection of 0.5 mg bevacizumab; the fellow eye underwent conventional laser photoablation. Digital retinal imaging and fluorescein angiography (FA) were performed at an average of 4 years after treatment in follow-up after these studies performed at treatment and 9 months. Main Outcome Measures: Fluorescein angiograms were examined by 2 experts to document retinal and choroidal findings. Results: Among the 20 bevacizumab-treated eyes available at 4 years of age, all showed abnormalities at the periphery (avascular area, vessel leakage, shunts, abnormal vessel branching, and tangles) or the posterior pole (hyperfluorescent lesions, absence of foveal avascular zone). These lesions were not observed in the majority of the lasered eyes. Among the 19 laser-treated eyes, leakage was noted in 1 eye, shunts and tangles were noted in 3 eyes, and macular abnormalities were noted in 3 eyes. Conclusions: Fluorescein angiography has shown potentially serious and long-term ocular effects that are present more commonly after treatment with bevacizumab for acute-phase ROP than after laser.
Lingua originaleEnglish
pagine (da-a)218-226
Numero di pagine9
RivistaOphthalmology
Volume125
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Angiogenesis Inhibitors
  • Bevacizumab
  • Dose-Response Relationship, Drug
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Infant
  • Infant, Newborn
  • Intravitreal Injections
  • Laser Coagulation
  • Male
  • Retina
  • Retinopathy of Prematurity
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A

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