Follow-up of IgD-kappa multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report

Elena De Santis, Cecilia Zuppi, Serena Masi, Iole Cordone, Francesco Pisani, Fabrizio Mattei, Laura Conti, Giovanni Cigliana

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Immunoglobulin (Ig)D-kappa multiple myeloma (MM) is a rare neoplastic disease characterized by an aggressive and rapidly progressing course, which constitutes only a very small proportion of all MM cases. In the present report, the clinical case of a 51-year-old Caucasian woman diagnosed with IgD-kappa MM is described. The patient underwent different chemotherapeutic treatments subsequently to a single autologous stem cell transplantation. Despite the inherent difficulty of monitoring IgD levels and performing serum immunofixation electrophoresis, the clinical outcome of the patient was almost uniquely monitored by measuring the levels of kappa and lambda free light chains (FLCs) and total heavy chain IgD. The data suggest the non-invasive potential and usefulness of FLCs evaluation for early detection of stringent complete remission, follow-up and early detection of disease relapse. In addition, this diagnostic procedure has successfully been employed for the therapeutic monitoring of the present patient, and may represent a very helpful, non-invasive tool for the follow-up of IgD myeloma patients without the requirement of serial bone marrow aspirate.
Lingua originaleEnglish
pagine (da-a)1884-1888
Numero di pagine5
RivistaOncology Letters
Volume12
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • minimal residual disease
  • multiple myeloma

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