Focusing in multiwell potentials: Applications to ion channels

Fausto Borgonovi, Luca Ponzoni, Giuseppe Celardo, G. L. Celardo, L. Kaplan, A. Kargol

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

1 Citazioni (Scopus)

Abstract

We investigate nonequilibrium stationary distributions induced by stochastic dichotomous noise in double-well and multiwell models of ion channel gating kinetics. The channel kinetics is analyzed using both overdamped Langevin equations and master equations. With the Langevin equation approach we show a nontrivial focusing effect due to the external stochastic noise, namely, the concentration of the probability distribution in one of the two wells of a double-well system or in one or more of the wells of the multiwell model. In the multiwell system, focusing in the outer wells is shown to be achievable under physiological conditions, while focusing in the central wells has proved possible so far only at very low temperatures. We also discuss the strength of the focusing effect and obtain the conditions necessary for maximal focusing to appear. These conditions cannot be predicted by a simple master equation approach.
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaPHYSICAL REVIEW E, STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS
Volume87
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • classical transport
  • ion channels

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