fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

Gabriella Silvestri, Luca Padua, Pietro Caliandro, Maria Laura Ester Bianchi, Marcella Masciullo, Paolo Maria Rossini, Chiara Simbolotti, Giuseppina Russo

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

11 Citazioni (Scopus)

Abstract

Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).
Lingua originaleEnglish
pagine (da-a)2269-2276
Numero di pagine8
RivistaClinical Neurophysiology
Volume124
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • fNIRS
  • myotonic dystrophy

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