fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

Pietro Caliandro; Gabriella Silvestri; Luca Padua; Maria Laura Ester Bianchi; Chiara Simbolotti; Giuseppina Russo; Marcella Masciullo; Paolo Maria Rossini

doi:10.1016/j.clinph.2013.05.010

fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

Pietro Caliandro, Gabriella Silvestri, Luca Padua, Maria Laura Ester Bianchi, Chiara Simbolotti, Giuseppina Russo, Marcella Masciullo, Paolo Maria Rossini

IRCCS Fondazione Don Carlo Gnocchi - Milano

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

11 Citazioni (Scopus)

Abstract

Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Clinical Neurophysiology
DOI	https://doi.org/10.1016/j.clinph.2013.05.010
Stato di pubblicazione	Pubblicato - 2013

Keywords

fNIRS
myotonic dystrophy

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10.1016/j.clinph.2013.05.010

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title = "fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1",

abstract = "Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).",

keywords = "fNIRS, myotonic dystrophy, fNIRS, myotonic dystrophy",

author = "Pietro Caliandro and Gabriella Silvestri and Luca Padua and Bianchi, {Maria Laura Ester} and Chiara Simbolotti and Giuseppina Russo and Marcella Masciullo and Rossini, {Paolo Maria}",

year = "2013",

doi = "10.1016/j.clinph.2013.05.010",

language = "English",

pages = "N/A--N/A",

journal = "Clinical Neurophysiology",

issn = "1872-8952",

publisher = "Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114",

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TY - JOUR

T1 - fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

AU - Caliandro, Pietro

AU - Silvestri, Gabriella

AU - Padua, Luca

AU - Bianchi, Maria Laura Ester

AU - Simbolotti, Chiara

AU - Russo, Giuseppina

AU - Masciullo, Marcella

AU - Rossini, Paolo Maria

PY - 2013

Y1 - 2013

N2 - Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).

AB - Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).

KW - fNIRS

KW - myotonic dystrophy

KW - fNIRS

KW - myotonic dystrophy

UR - http://hdl.handle.net/10807/100607

U2 - 10.1016/j.clinph.2013.05.010

DO - 10.1016/j.clinph.2013.05.010

M3 - Article

SN - 1872-8952

SP - N/A-N/A

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

ER -

fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1

Abstract

Keywords

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