TY - JOUR
T1 - fNIRS evaluation during a phonemic verbal task reveals prefrontal hypometabolism in patients affected by myotonic dystrophy type 1
AU - Caliandro, Pietro
AU - Silvestri, Gabriella
AU - Padua, Luca
AU - Bianchi, Maria Laura Ester
AU - Simbolotti, Chiara
AU - Russo, Giuseppina
AU - Masciullo, Marcella
AU - Rossini, Paolo Maria
PY - 2013
Y1 - 2013
N2 - Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).
AB - Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy in adults, is characterized by a multisystem involvement. Cognitive involvement predominantly affecting frono-temporal functions is an established clinical feature in this disorder. Brain imaging and metabolic studies showed a predominant involvement of fronto-temporal regions in DM1 patients, yet correlation studies among these findings and neuropsychological data gave contrasting results. In order to contribute to clarify the relationship between the metabolic changes documented in the frontal cortex of DM1 patients and a related cognitive task, we applied the functional near-infrared spectroscopy (fNIRS) during the execution of a phonemic verbal fluency task (pVFT).
KW - fNIRS
KW - myotonic dystrophy
KW - fNIRS
KW - myotonic dystrophy
UR - http://hdl.handle.net/10807/100607
U2 - 10.1016/j.clinph.2013.05.010
DO - 10.1016/j.clinph.2013.05.010
M3 - Article
SN - 1872-8952
SP - N/A-N/A
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -