TY - JOUR
T1 - Flow Cytofluorimetric Analysis of Anti-LRP4 (LDL Receptor-Related Protein 4) Autoantibodies in Italian Patients with Myasthenia Gravis
AU - Marino, Mariapaola
AU - Scuderi, Flavia
AU - Samengo, Daniela Maria
AU - Saltelli, Giorgia
AU - Maiuri, Maria Teresa
AU - Shen, Chengyong
AU - Mei, Lin
AU - Sabatelli, Mario
AU - Pani, Giovambattista
AU - Antonini, Giovanni
AU - Evoli Stampanoni-B, Amelia
AU - Bartoccioni, Emanuela
PY - 2015
Y1 - 2015
N2 - Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.
AB - Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while autoantibodies to muscle-specific tyrosine kinase (MuSK) have been detected in half (5%) of the remaining 10%. Recently, the low-density lipoprotein receptor-related protein 4 (LRP4), identified as the agrin receptor, has been recognized as a third autoimmune target in a significant portion of the double sero-negative (dSN) myasthenic individuals, with variable frequency depending on different methods and origin countries of the tested population. There is also convincing experimental evidence that anti-LRP4 autoantibodies may cause MG.
KW - autoantibody
KW - autoimmunity
KW - autoantibody
KW - autoimmunity
UR - http://hdl.handle.net/10807/70194
UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135378
U2 - 10.1371/journal.pone.0135378
DO - 10.1371/journal.pone.0135378
M3 - Article
SN - 1932-6203
VL - 10
SP - e0135378-e0135378
JO - PLoS One
JF - PLoS One
ER -