TY - JOUR
T1 - Flares as dynamic predictive factor of response to adalimumab in hidradenitis suppurativa: real-life data
AU - Caposiena Caro, Raffaele D.
AU - Chiricozzi, Andrea
AU - Sechi, Andrea
AU - Molinelli, Elisa
AU - Venturini, Marina
AU - Candi, Eleonora
AU - Malvaso, Dalma
AU - Peris, Ketty
AU - Patrizi, Annalisa
AU - Offidani, Annamaria
AU - Calzavara-Pinton, Piergiacomo
AU - Bianchi, Luca
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Hidradenitis suppurativa (HS) is characterized by periodic worsening of both clinical manifestations and symptoms. The aim of this study was to investigate the role of flare outbreak as a possible predictive factor of response to adalimumab. METHODS: One hundred fifteen HS patients in treatment with adalimumab, with moderate-severe HS, 3 abscesses and inflammatory-nodules (ANs) from 5 Italian centers were included in this retrospective analysis. The information about gender, ages at onset/baseline, therapeutic delay, family history, body mass index, smoking, comorbidities, phenotypes, body areas, severity indexes at baseline was collected. Baseline characteristics, total number and timeline of flares were analyzed by regression and survival analysis with Hidradenitis Suppurativa Clinical Response (HiSCR). RESULTS: During the observational period, 80.9% of patients developed flares, detecting 252 flares. Univariate model identified five factors as-sociated with the absence of response: age (P=0.020), comorbidities (P=0.030), genital-perineal involvement (P=0.004), no response at week 12 (P=0.027), and flares outbreak (P=0.010). Joint analysis of recurrent and terminal events showed a positive correlation between flare recurrence and no response (P<0.001). Among the identified variables associated with poor response to the therapy: occurrence of a flare before week 12 was the one with the highest risk of no response (P<0.001). CONCLUSIONS: The analysis of a "dynamic" variable, as flares evaluation together with an appropriate clinical baseline assessment can be a useful approach to predict the middle-long-term response to adalimumab. (Cite this article as: Caposiena Caro RD, Chiricozzi A, Sechi A, Molinelli E, Venturini M, Candi E, et al. Flares as dynamic predictive factor of re-sponse to adalimumab in hidradenitis suppurativa, real-life data. Ital J Dermatol Venereol 2022;157:240-6. DOI: 10.23736/S2784-8671.21.07049-3)
AB - BACKGROUND: Hidradenitis suppurativa (HS) is characterized by periodic worsening of both clinical manifestations and symptoms. The aim of this study was to investigate the role of flare outbreak as a possible predictive factor of response to adalimumab. METHODS: One hundred fifteen HS patients in treatment with adalimumab, with moderate-severe HS, 3 abscesses and inflammatory-nodules (ANs) from 5 Italian centers were included in this retrospective analysis. The information about gender, ages at onset/baseline, therapeutic delay, family history, body mass index, smoking, comorbidities, phenotypes, body areas, severity indexes at baseline was collected. Baseline characteristics, total number and timeline of flares were analyzed by regression and survival analysis with Hidradenitis Suppurativa Clinical Response (HiSCR). RESULTS: During the observational period, 80.9% of patients developed flares, detecting 252 flares. Univariate model identified five factors as-sociated with the absence of response: age (P=0.020), comorbidities (P=0.030), genital-perineal involvement (P=0.004), no response at week 12 (P=0.027), and flares outbreak (P=0.010). Joint analysis of recurrent and terminal events showed a positive correlation between flare recurrence and no response (P<0.001). Among the identified variables associated with poor response to the therapy: occurrence of a flare before week 12 was the one with the highest risk of no response (P<0.001). CONCLUSIONS: The analysis of a "dynamic" variable, as flares evaluation together with an appropriate clinical baseline assessment can be a useful approach to predict the middle-long-term response to adalimumab. (Cite this article as: Caposiena Caro RD, Chiricozzi A, Sechi A, Molinelli E, Venturini M, Candi E, et al. Flares as dynamic predictive factor of re-sponse to adalimumab in hidradenitis suppurativa, real-life data. Ital J Dermatol Venereol 2022;157:240-6. DOI: 10.23736/S2784-8671.21.07049-3)
KW - Adalimumab
KW - Guidelines as topic
KW - Hidradenitis Suppurativa
KW - Hidradenitis suppurativa
KW - Humans
KW - Retrospective Studies
KW - Severity of Illness Index
KW - Treatment Outcome
KW - suppurativa
KW - Adalimumab
KW - Guidelines as topic
KW - Hidradenitis Suppurativa
KW - Hidradenitis suppurativa
KW - Humans
KW - Retrospective Studies
KW - Severity of Illness Index
KW - Treatment Outcome
KW - suppurativa
UR - http://hdl.handle.net/10807/214088
U2 - 10.23736/S2784-8671.21.07049-3
DO - 10.23736/S2784-8671.21.07049-3
M3 - Article
SN - 2784-8450
VL - 157
SP - 240
EP - 246
JO - Italian Journal of Dermatology and Venereology
JF - Italian Journal of Dermatology and Venereology
ER -