FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA

M Coxfroncillo; Maurizio Genuardi; J Bajer; E Livdi; G Adorno; A Venditti; Maria Claudia Masi; P Giudiceandrea; G Neri; G Papa

FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA

M Coxfroncillo, Maurizio Genuardi, J Bajer, E Livdi, G Adorno, A Venditti, Maria Claudia Masi, P Giudiceandrea, G Neri, G Papa

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.

Lingua originale	Inglese
pagine (da-a)	82-85
Numero di pagine	4
Rivista	Cancer Genetics and Cytogenetics
Volume	79
Stato di pubblicazione	Pubblicato - 1995

Keywords

GENE
MLL
TRANSLOCATIONS

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title = "FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA",

abstract = "Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.",

keywords = "GENE, MLL, TRANSLOCATIONS, GENE, MLL, TRANSLOCATIONS",

author = "M Coxfroncillo and Maurizio Genuardi and J Bajer and E Livdi and G Adorno and A Venditti and Masi, {Maria Claudia} and P Giudiceandrea and G Neri and G Papa",

year = "1995",

language = "English",

volume = "79",

pages = "82--85",

journal = "Cancer Genetics and Cytogenetics",

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TY - JOUR

T1 - FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA

AU - Coxfroncillo, M

AU - Genuardi, Maurizio

AU - Bajer, J

AU - Livdi, E

AU - Adorno, G

AU - Venditti, A

AU - Masi, Maria Claudia

AU - Giudiceandrea, P

AU - Neri, G

AU - Papa, G

PY - 1995

Y1 - 1995

N2 - Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.

AB - Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis revealed the presence of the translocation (8;21)(q22;q22) as the sole chromosome anomaly. In spite of the rather good prognosis patients suffering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early relapse resistant to any treatment and meningeal localization. Death occurred within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.

KW - GENE

KW - MLL

KW - TRANSLOCATIONS

KW - GENE

KW - MLL

KW - TRANSLOCATIONS

UR - http://hdl.handle.net/10807/219930

M3 - Article

SN - 0165-4608

VL - 79

SP - 82

EP - 85

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

ER -

FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA

Abstract

Keywords

Altri file e collegamenti

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