First-phase insulin secretion: can its evaluation direct therapeutic approaches?

Gianfranco Di Giuseppe; Gea Ciccarelli; Laura Soldovieri; Umberto Capece; Chiara M A Cefalo; Simona Moffa; Enrico C Nista; Michela Brunetti; Francesca Cinti; Antonio Gasbarrini; Alfredo Pontecorvi; Andrea Giaccari; Teresa Mezza

doi:10.1016/j.tem.2023.02.001

First-phase insulin secretion: can its evaluation direct therapeutic approaches?

Gianfranco Di Giuseppe, Gea Ciccarelli, Laura Soldovieri, Umberto Capece, Chiara M A Cefalo, Simona Moffa, Enrico C Nista, Michela Brunetti, Francesca Cinti, Antonio Gasbarrini, Alfredo Pontecorvi, Andrea Giaccari^*, Teresa Mezza

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with beta cell function and mass. Starting from pathophysiology, we investigate the impact of impaired secretion on glucose homeostasis and explore postmeal hyperglycemia as the main clinical feature, underlining its rele-vance in the management of the disease. We also review dietary and pharmaco-logical approaches aimed at improving early secretory defects and restoring residual beta cell function. Furthermore, we discuss possible approaches to detect early secretory defects in clinical practice. By providing a journey through human and animal data, we attempt a unification of the recent evidence in an effort to offer a new outlook on beta cell secretion.

Lingua originale	Inglese
pagine (da-a)	216-230
Numero di pagine	15
Rivista	Trends in Endocrinology and Metabolism
Volume	34
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/j.tem.2023.02.001
Stato di pubblicazione	Pubblicato - 2023

All Science Journal Classification (ASJC) codes

Endocrinologia, Diabete e Metabolismo
Endocrinologia

Keywords

first phase
insulin secretion
postmeal hyperglycemia
type 2 diabetes
β cell function

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Accesso al documento

10.1016/j.tem.2023.02.001

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Cita questo

Di Giuseppe, G., Ciccarelli, G., Soldovieri, L., Capece, U., Cefalo, C. M. A., Moffa, S., Nista, E. C., Brunetti, M., Cinti, F., Gasbarrini, A., Pontecorvi, A., Giaccari, A., & Mezza, T. (2023). First-phase insulin secretion: can its evaluation direct therapeutic approaches? Trends in Endocrinology and Metabolism, 34(4), 216-230. https://doi.org/10.1016/j.tem.2023.02.001

@article{73fc3004013b4b7e981330146c1e5646,

title = "First-phase insulin secretion: can its evaluation direct therapeutic approaches?",

abstract = "Our work is aimed at unraveling the role of the first-phase insulin secretion in the natural history of type 2 diabetes mellitus (T2DM) and its interrelationship with insulin resistance and with beta cell function and mass. Starting from pathophysiology, we investigate the impact of impaired secretion on glucose homeostasis and explore postmeal hyperglycemia as the main clinical feature, underlining its rele-vance in the management of the disease. We also review dietary and pharmaco-logical approaches aimed at improving early secretory defects and restoring residual beta cell function. Furthermore, we discuss possible approaches to detect early secretory defects in clinical practice. By providing a journey through human and animal data, we attempt a unification of the recent evidence in an effort to offer a new outlook on beta cell secretion.",

keywords = "first phase, insulin secretion, postmeal hyperglycemia, type 2 diabetes, β cell function, first phase, insulin secretion, postmeal hyperglycemia, type 2 diabetes, β cell function",

author = "{Di Giuseppe}, Gianfranco and Gea Ciccarelli and Laura Soldovieri and Umberto Capece and Cefalo, {Chiara M A} and Simona Moffa and Nista, {Enrico C} and Michela Brunetti and Francesca Cinti and Antonio Gasbarrini and Alfredo Pontecorvi and Andrea Giaccari and Teresa Mezza",

year = "2023",

doi = "10.1016/j.tem.2023.02.001",

language = "English",

volume = "34",

pages = "216--230",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",