Fetal infection from rubeovirus or cytomegalovirus: correlation among maternal serological profiles, invasive diagnostic procedures, and long-term follow-up

Lucia Masini, Marco De Santis, Paola Cattani, Salvatore Mancuso, Giuseppe Noia, Francesco Pomini, Orazio Gaetano Ranno, Alessandro Caruso, M Scavo, R Grillo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

Different variables influence the possibility that maternal viral infection may be transmitted to the fetus, although not all fetal infections result in fetal "illness" with consequent fetopathy. As concerns the fetus, prenatal diagnosis includes invasive techniques necessary for fetal tissue sampling. These techniques carry some risks. The fetal infectious risk, as determined by maternal clinico-serological profile and according to sonographic investigation, always should be weighed against the risks and benefits of invasive diagnostic procedures. The present study re-elaborates the criteria necessary for defining fetal risk as related to the maternal serological profile. In the 26 mothers with rubeola infection, the incidence of fetal mortality was 7.7%. Fetal prognosis worsens with the precocity of eruption. In these cases the esantema is the most reliable prognostic element as an indication to perform the invasive procedure. In the 15 patients with cytomegalovirus infection, no fetal or postnatal losses occurred. Morbidity occurred in 13.3% of cases, and the two ill fetuses were classified in the same risk group. In this group of patients, the maternal serological profile is a significant predictor of fetal morbidity.
Lingua originaleEnglish
pagine (da-a)36-42
Numero di pagine7
RivistaJOURNAL OF MATERNAL FETAL MEDICINE
Volume7
DOI
Stato di pubblicazionePubblicato - 1998

Keywords

  • Amniotic Fluid
  • Antibodies, Viral
  • Cells, Cultured
  • Cytomegalovirus Infections
  • Female
  • Fetal Death
  • Fetal Diseases
  • Gestational Age
  • Humans
  • Immunoglobulin G
  • Immunoglobulin M
  • Infectious Disease Transmission, Vertical
  • Measles
  • Morbidity
  • Pregnancy
  • Pregnancy Complications, Infectious
  • Prenatal Diagnosis
  • Prognosis
  • Risk Factors

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