Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: An observational study

Paolo Rosati, Gian Franco Zannoni, Giovanni Vento, Alessandra Lio, Roberta Pastorino, Francesco Cota, Milena Tana, Chiara Tirone, Claudia Aurilia, Cinzia Ricci, Angela Paladini, Ilenia Mappa, Silvia Buongiorno, Costantino Romagnoli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

12 Citazioni (Scopus)

Abstract

Objective To investigate whether fetal growth restriction (FGR) diagnosis, based on pathological prenatal fetal Doppler velocimetry, is associated with bronchopulmonary dysplasia (BPD) independently of being small for gestational age (SGA) per se at birth among very preterm infants. Design Prospective, observational study. FGR was defined as failing fetal growth in utero and fetal Doppler velocimetry abnormalities. Setting Policlinico Universitario Agostino Gemelli, Roma, Italy. Patients Preterm newborns with gestational age ≤30 weeks and birth weight (BW) ≤1250 g. Main outcome measures Bronchopulmonary dysplasia. Results In the study period, 178 newborns were eligible for the study. Thirty-nine infants (22%) were considered fetal growth-restricted infants. Among the 154 survived babies at 36 weeks postmenstrual age, 12 out of 36 (33%) of the FGR group developed BPD versus 8 out of 118 (7%) of the NO-FGR group (p<0.001). BPD rate was sixfold higher among the SGA-FGR infants compared with the SGA-NO-FGR infants. In a multivariable model, FGR was significantly associated with BPD risk (OR 5.1, CI 1.4 to 18.8, p=0.01), independently from BW z-score that still remains a strong risk factor (OR 0.5, CI 0.3 to 0.9, p=0.01). Conclusion Among SGA preterm infants, BPD risk dramatically increases when placenta dysfunction is the surrounding cause of low BW. Antenatal fetal Doppler surveillance could be a useful tool for studying placenta wellness and predicting BPD risk among preterm babies. Further research is needed to better understand how FGR affects lung development.
Lingua originaleEnglish
pagine (da-a)e015232-N/A
RivistaBMJ Open
Volume7
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Medicine (all)
  • antenatal fetal Doppler velocimetry
  • bronchopulmonary dysplasia
  • fetal growth restriction
  • placenta insufficiency
  • preterm newborns

Fingerprint

Entra nei temi di ricerca di 'Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: An observational study'. Insieme formano una fingerprint unica.

Cita questo