Ferulic acid (FA) belongs to the family of phenolic acids and is very abundant in fruits and vegetables. Over the past years, several studies have shown that FA acts as a potent antioxidant by scavenging free radicals and enhancing the cell stress response through the up-regulation of cytoprotective systems, e.g. heme oxygenase-1, heat shock protein 70, extracellular signal-regulated kinase 1/2 and the proto-oncogene Akt. Furthermore, FA was shown to inhibit the expression and/or activity of cytotoxic enzymes, including inducible nitric oxide synthase, caspases and cyclooxygenase-2. Based on this evidence, FA has been proposed as a potential treatment for many disorders including Alzheimer's disease, cancer, cardiovascular diseases, diabetes mellitus and skin disease. However, despite the great abundance of preclinical research, only a few studies were carried out in humans, the majority of which used foods containing FA, and therefore the clinical efficacy of this mode of administration needs to be further documented. New efforts and resources are needed in clinical research for the complete evaluation of FA therapeutic potential in chronic diseases.
Lingua originaleEnglish
pagine (da-a)185-195
Numero di pagine11
RivistaFood and Chemical Toxicology
Stato di pubblicazionePubblicato - 2014


  • Aging
  • Alzheimer’s disease
  • BR
  • BV
  • BVR
  • Biliverdin reductase
  • C(max)
  • CAT
  • CCNA2
  • CCNB1
  • CEP2
  • CYP
  • ERK 1/2
  • FA
  • FAEE
  • Ferulic acid
  • Free radicals
  • GFAP
  • HO
  • Heme oxygenase
  • Hsp
  • IL-1β
  • LD
  • Neurodegenerative disorders
  • ODC1
  • PPB
  • RAB GTPase activating protein 1
  • ROS
  • SF
  • SMC1L1
  • SOD
  • T(max)
  • TGF-β
  • THD
  • UDP-glucuronosyltransferase
  • UGT
  • amyloid-β-peptide
  • bilirubin
  • biliverdin
  • biliverdin reductase
  • catalase
  • centrosomal protein 2
  • cytochrome P-450
  • eNOS
  • endothelial nitric oxide synthase
  • extracellular signal-related kinase 1/2
  • ferulic acid
  • ferulic acid ethyl ester
  • gene encoding for G2/mitotic-specific cyclin-B1
  • gene encoding for cyclin-A2
  • gene encoding for ornithine decarboxylase
  • glial fibrillary acidic protein
  • h
  • heat shock protein
  • heme oxygenase
  • hour(s)
  • iNOS
  • inducible nitric oxide synthase
  • interleukin-1β
  • lethal dose
  • peak plasma concentration
  • plasma protein binding
  • reactive oxygen species
  • sodium ferulate
  • structural maintenance of chromosomes 1-like 1
  • superoxide dismutase
  • thiazolidinedione(s)
  • time to reach the C(max)
  • transforming growth factor-β


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