Fertility preservation in patients with BRCA mutations or Lynch syndrome

Giacomo Corrado; Claudia Marchetti; Rita Trozzi; Giovanni Scambia; Anna Fagotti

doi:10.1136/ijgc-2020-002071

Fertility preservation in patients with BRCA mutations or Lynch syndrome

Giacomo Corrado, Claudia Marchetti, Rita Trozzi, Giovanni Scambia, Anna Fagotti

Risultato della ricerca: Contributo in rivista › Articolo in rivista

1 Citazioni (Scopus)

Abstract

Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

Lingua originale	English
pagine (da-a)	332-338
Numero di pagine	7
Rivista	International Journal of Gynecological Cancer
Volume	31
DOI	https://doi.org/10.1136/ijgc-2020-002071
Stato di pubblicazione	Pubblicato - 2021

Keywords

BRCA1 protein
BRCA2 protein
lynch syndrome II

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10.1136/ijgc-2020-002071

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title = "Fertility preservation in patients with BRCA mutations or Lynch syndrome",

abstract = "Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.",

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AU - Corrado, Giacomo

AU - Marchetti, Claudia

AU - Trozzi, Rita

AU - Scambia, Giovanni

AU - Fagotti, Anna

PY - 2021

Y1 - 2021

N2 - Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

AB - Guidelines and expert consensus are lacking on fertility preservation in BRCA mutation carriers and in patients with Lynch syndrome. The safety of fertility preservation in this setting is still a topic of debate and multiple factors need to be carefully considered. The aim of this review was to analyze the reproductive potential of women harboring a genetic mutation affecting the DNA repair system and explore the efficacy and safety of existing fertility preservation strategies in these patients.

KW - BRCA1 protein

KW - BRCA2 protein

KW - lynch syndrome II

KW - BRCA1 protein

KW - BRCA2 protein

KW - lynch syndrome II

UR - http://hdl.handle.net/10807/178358

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DO - 10.1136/ijgc-2020-002071

M3 - Article

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VL - 31

SP - 332

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JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

ER -

Fertility preservation in patients with BRCA mutations or Lynch syndrome

Abstract

Keywords

Accesso al documento

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