Fertility and hypopituitarism

Alfredo Pontecorvi, Domenico Milardi, Antonella Giampietro, Laura De Marinis Grasso, R Baldelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

Fertility outcomes in hypopituitaric women are about half of those reported in isolated hypogonadotropic hypogonadism; GH deficiency (GHD) is a major contributor to poor pregnancy rate. GH seems to play a physiological role in the control of male sexual maturation and adult reproductive functions. In males, GH regulates gonadal differentiation, steroidogenesis, and gametogenesis, as well as gonadotropin secretion and responsiveness. In females, GH has a role not only as a modulator on gonadotropins, mediated by the property of IGF-I to amplify the action of both LH and FSH on granulosa, but also, through a direct GH action, on follicular maturation. GH treatment seems to play an important role in the sensibilization of ovary responsivity and uterine morpholgy in GHD patients. Since GH, directly or indirectly via IGF-I, regulates reproductive functions at all levels of the hyophyseal-pituitary-gonadal, it should always be tested as a possible cause of unexplained infertility.
Lingua originaleEnglish
pagine (da-a)71-74
Numero di pagine4
RivistaJournal of Endocrinological Investigation
Volume31
Stato di pubblicazionePubblicato - 2008

Keywords

  • Female
  • Fertility
  • Human Growth Hormone
  • Humans
  • Hypopituitarism
  • Infertility
  • Male
  • Reproduction

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