TY - JOUR
T1 - Fecal microbiota transplantation: Past, present and future perspectives
AU - Bibbo', Stefano
AU - Ianiro, Gianluca
AU - Gasbarrini, Antonio
AU - Cammarota, Giovanni
PY - 2017
Y1 - 2017
N2 - Gut microbiota is known to play a main role in regulating both health and disease in humans. Strategies for the therapeutic modulation of gut microbiota are therefore expected to give a relevant contribution in the management of disorders associated with its impairment. Among these options, one of the most renowned is fecal microbiota transplantation (FMT). A growing body of evidence showed clearly that FMT is an effective treatment against recurrent Clostridium difficile infection. Moreover, it was shown to be a promising therapy for the management of several noncommunicable disorders, including inflammatory bowel diseases and metabolic disorders. Standardization of procedural protocols for different disorders will surely increase the therapeutic power of FMT. The aim of this narrative review was to make an overview of methodology, indications, and future perspectives of FMT for the management of disorders associated with gut microbiota impairment.
AB - Gut microbiota is known to play a main role in regulating both health and disease in humans. Strategies for the therapeutic modulation of gut microbiota are therefore expected to give a relevant contribution in the management of disorders associated with its impairment. Among these options, one of the most renowned is fecal microbiota transplantation (FMT). A growing body of evidence showed clearly that FMT is an effective treatment against recurrent Clostridium difficile infection. Moreover, it was shown to be a promising therapy for the management of several noncommunicable disorders, including inflammatory bowel diseases and metabolic disorders. Standardization of procedural protocols for different disorders will surely increase the therapeutic power of FMT. The aim of this narrative review was to make an overview of methodology, indications, and future perspectives of FMT for the management of disorders associated with gut microbiota impairment.
KW - Clostridium difficile
KW - Endocrinology, Diabetes and Metabolism
KW - Fecal microbiota transplantation
KW - Gastroenterology
KW - Gastrointestinal microbiome
KW - Inflammatory bowel diseases
KW - Internal Medicine
KW - Irritable bowel syndrome
KW - Nutrition and Dietetics
KW - Clostridium difficile
KW - Endocrinology, Diabetes and Metabolism
KW - Fecal microbiota transplantation
KW - Gastroenterology
KW - Gastrointestinal microbiome
KW - Inflammatory bowel diseases
KW - Internal Medicine
KW - Irritable bowel syndrome
KW - Nutrition and Dietetics
UR - http://hdl.handle.net/10807/113175
UR - https://www.minervamedica.it/en/getpdf/6vzqq83pgiwpt3xsdizyp7nx0iy9tjgmdybqcegjgxbyeuxifi4jkwzzc9j0ywfd9e9oenvzvgypag2zgm4xia%253d%253d/r08y2017n04a0420.pdf
U2 - 10.23736/S1121-421X.17.02374-1
DO - 10.23736/S1121-421X.17.02374-1
M3 - Article
SN - 1121-421X
VL - 63
SP - 420
EP - 430
JO - Minerva Gastroenterologica e Dietologica
JF - Minerva Gastroenterologica e Dietologica
ER -