Fecal but not serum calprotectin is a potential marker of GVHD after stem cell transplantation.

Simona Sica, Patrizia Chiusolo, Elisabetta Metafuni, Sabrina Giammarco, Daniela Giovanna De Ritis, Cecilia Zuppi, Andrea Bacigalupo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

Abstract Gastrointestinal graft-versus-host disease (GvHD) represents a life-threatening complication after stem cell transplantation. Differential diagnosis between gut GvHD and other causes of diarrhea after HSCT is still subjected to endoscopy and histological findings. The research for a reliable biomarker for gut GvHD might allow an early diagnosis of this condition and a consequent prompt treatment that could reduce unfavorable outcomes. Recently, fecal calprotectin was reported as reliable marker of gut involvement. We would evaluate if serum instead of fecal calprotectin could be considered a possible biomarker of gut GvHD. Serum calprotectin was measured in a cohort of 54 patients submitted to allogeneic stem cell transplantation using ELISA assay. For a subset of 21 patients, calprotectin serum levels were compared with fecal calprotectin detection. Contrary to fecal calprotectin, we found only a trend to high level of serum calprotectin for GvHD development and gut involvement, but statistical difference was not reached. Fecal but not serum calprotectin could be considered as possible biomarker for gut GvHD.
Lingua originaleEnglish
pagine (da-a)2974-2981
Numero di pagine8
RivistaAnnals of Hematology
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Fecal but not serum calprotectin

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