TY - JOUR
T1 - Fatigue in kidney transplantation: A systematic review and meta-analysis
AU - Bossola, Maurizio
AU - Arena, Maria
AU - Urciuolo, Federica
AU - Antocicco, Manuela
AU - Pepe, Gilda
AU - Calabro', Giovanna Elisa
AU - Cianfrocca, Claudia
AU - Di Stasio, Enrico
PY - 2021
Y1 - 2021
N2 - Fatigue is still present in up to 40–50% of kidney transplant recipients (KTR), the results of studies comparing the prevalence among patients on hemodialysis (HD) and KTR led to conflicting results. Fatigue correlates include inflammation, symptoms of depression, sleep disorders and obesity. Fatigue in KTR leads to significant functional impairment, it is common among KTR poorly adherent to immunosuppressive therapy and is associated with a serious deterioration of quality of life. The following databases were searched for relevant studies up to November 2020: Medline, PubMed, Web of Science and the Cochrane Library. Several studies have compared the prevalence and severity of fatigue between KTR and hemodialysis or healthy patients. They have shown that fatigue determines a significant functional deterioration with less chance of having a paid job and a significant change in quality of life. The aim of the review is to report methods to assess fatigue and its prevalence in KTR patients, compared to HD subjects and define the effects of fatigue on health status and daily life. There is no evidence of studies on the treatment of this symptom in KTR. Efforts to identify and treat fatigue should be a priority to improve the quality of life of KTR.
AB - Fatigue is still present in up to 40–50% of kidney transplant recipients (KTR), the results of studies comparing the prevalence among patients on hemodialysis (HD) and KTR led to conflicting results. Fatigue correlates include inflammation, symptoms of depression, sleep disorders and obesity. Fatigue in KTR leads to significant functional impairment, it is common among KTR poorly adherent to immunosuppressive therapy and is associated with a serious deterioration of quality of life. The following databases were searched for relevant studies up to November 2020: Medline, PubMed, Web of Science and the Cochrane Library. Several studies have compared the prevalence and severity of fatigue between KTR and hemodialysis or healthy patients. They have shown that fatigue determines a significant functional deterioration with less chance of having a paid job and a significant change in quality of life. The aim of the review is to report methods to assess fatigue and its prevalence in KTR patients, compared to HD subjects and define the effects of fatigue on health status and daily life. There is no evidence of studies on the treatment of this symptom in KTR. Efforts to identify and treat fatigue should be a priority to improve the quality of life of KTR.
KW - Assessment
KW - Fatigue
KW - Kidney transplant recipients
KW - Patients on hemodialysis
KW - Assessment
KW - Fatigue
KW - Kidney transplant recipients
KW - Patients on hemodialysis
UR - http://hdl.handle.net/10807/201202
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8147914/pdf/diagnostics-11-00833.pdf
U2 - 10.3390/diagnostics11050833
DO - 10.3390/diagnostics11050833
M3 - Article
SN - 2075-4418
VL - 11
SP - 833
EP - 844
JO - Diagnostics
JF - Diagnostics
ER -
