Introduction: Ranitidine hydrochloride (Zantac®), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record. Anaphylactic reaction to ranitidine is an extremely rare event and a related death has never been described in the literature. Case presentation: We present the clinical history, histological and toxicological data of a 51-year-old man with negative anamnesis for allergic events, who died suddenly after the intravenous administration of one phial of Zantac® 50 mg prescribed as a routine post-surgical prophylaxis for stress ulcer. Conclusion: Although the incidence of anaphylactic reactions related to ranitidine is low, caution needs to be exercised on administration of this drug. In addition, further study is needed to define strategies for the prevention of adverse drug reactions in hospitalized patients. © 2008 Oliva et al; licensee BioMed Central Ltd.
Lingua originaleEnglish
pagine (da-a)232-232
Numero di pagine1
RivistaJournal of Medical Case Reports
Stato di pubblicazionePubblicato - 2008


  • alfuzosin
  • anamnesis
  • anaphylactic shock
  • article
  • autopsy
  • blood toxicity
  • brain edema
  • case report
  • cefodizime
  • consciousness disorder
  • drug fatality
  • drug hypersensitivity
  • dyspnea
  • histopathology
  • hospital admission
  • human
  • hypotension
  • immediate type hypersensitivity
  • lung congestion
  • lung edema
  • male
  • petechia
  • prescription
  • priority journal
  • prostate hypertrophy
  • ranitidine, adult
  • stress ulcer
  • transurethral resection
  • wheezing


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