TY - JOUR
T1 - Fatal injection of ranitidine: a case report
AU - Oliva, Antonio
AU - Partemi, Sara
AU - Arena, Vincenzo
AU - De Giorgio, Fabio
AU - Colecchi, Catia
AU - Fucci, Nadia
AU - Pascali, Vincenzo Lorenzo
PY - 2008
Y1 - 2008
N2 - ABSTRACT: INTRODUCTION: Ranitidine hydrochloride (Zantac(R)), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record. Anaphylactic reaction to ranitidine is an extremely rare event and a related death has never been described in the literature. CASE PRESENTATION: We present the clinical history, histological and toxicological data of a 51-year-old man with negative anamnesis for allergic events, who died suddenly after the intravenous administration of one phial of Zantac(R) 50 mg prescribed as a routine post-surgical prophylaxis for stress ulcer. CONCLUSION: Although the incidence of anaphylactic reactions related to ranitidine is low, caution needs to be exercised on administration of this drug. In addition, further study is needed to define strategies for the prevention of adverse drug reactions in hospitalized patients.
AB - ABSTRACT: INTRODUCTION: Ranitidine hydrochloride (Zantac(R)), a histamine-2-receptor antagonist, is a widely used medication with an excellent safety record. Anaphylactic reaction to ranitidine is an extremely rare event and a related death has never been described in the literature. CASE PRESENTATION: We present the clinical history, histological and toxicological data of a 51-year-old man with negative anamnesis for allergic events, who died suddenly after the intravenous administration of one phial of Zantac(R) 50 mg prescribed as a routine post-surgical prophylaxis for stress ulcer. CONCLUSION: Although the incidence of anaphylactic reactions related to ranitidine is low, caution needs to be exercised on administration of this drug. In addition, further study is needed to define strategies for the prevention of adverse drug reactions in hospitalized patients.
KW - death
KW - ranitidine
KW - death
KW - ranitidine
UR - https://publicatt.unicatt.it/handle/10807/6798
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=48549103140&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=48549103140&origin=inward
U2 - 10.1186/1752-1947-2-232
DO - 10.1186/1752-1947-2-232
M3 - Article
SN - 1752-1947
VL - 2
SP - 230
EP - 232
JO - Journal of Medical Case Reports
JF - Journal of Medical Case Reports
IS - Luglio
ER -