Fat mass largely contributes to insulin mediated glucose uptake in morbidly obese subjects

D. Gniuli; G. Castagneto-Gissey; Amerigo Iaconelli; Laura Leccesi; Geltrude Mingrone

doi:10.1038/ijo.2010.99

Fat mass largely contributes to insulin mediated glucose uptake in morbidly obese subjects

D. Gniuli, G. Castagneto-Gissey, Amerigo Iaconelli, Laura Leccesi, Geltrude Mingrone

University of Kent

Risultato della ricerca: Contributo in rivista › Articolo in rivista

7 Citazioni (Scopus)

Abstract

The aim of this study is to investigate the effect of body size on insulin-mediated, whole-body glucose uptake (M-value) in morbidly obese (MO) subjects, who have large amounts of fat mass. Furthermore, we aimed at verifying which surrogate insulin-sensitivity index can better substitute the euglycemic clamp values and whether the insulin secretion/insulin resistance index is meaningful also in MO subjects.

Lingua originale	English
pagine (da-a)	1726-1732
Numero di pagine	7
Rivista	International journal of obesity (2005)
Volume	34
DOI	https://doi.org/10.1038/ijo.2010.99
Stato di pubblicazione	Pubblicato - 2010

Keywords

Adult
Area Under Curve
Blood Glucose
Body Mass Index
Body Size
Body Weight
C-Peptide
Case-Control Studies
Cross-Sectional Studies
Fasting
Female
Glucose
Glucose Clamp Technique
Glucose Tolerance Test
Humans
Insulin
Insulin Resistance
Male
Obesity, Morbid

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10.1038/ijo.2010.99

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AU - Gniuli, D.

AU - Castagneto-Gissey, G.

AU - Iaconelli, Amerigo

AU - Leccesi, Laura

AU - Mingrone, Geltrude

PY - 2010

Y1 - 2010

N2 - The aim of this study is to investigate the effect of body size on insulin-mediated, whole-body glucose uptake (M-value) in morbidly obese (MO) subjects, who have large amounts of fat mass. Furthermore, we aimed at verifying which surrogate insulin-sensitivity index can better substitute the euglycemic clamp values and whether the insulin secretion/insulin resistance index is meaningful also in MO subjects.

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KW - Body Mass Index

KW - Body Size

KW - Body Weight

KW - C-Peptide

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Fasting

KW - Female

KW - Glucose

KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

KW - Humans

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KW - Insulin Resistance

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KW - Body Weight

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KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Fasting

KW - Female

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KW - Glucose Clamp Technique

KW - Glucose Tolerance Test

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KW - Insulin

KW - Insulin Resistance

KW - Male

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ER -

Fat mass largely contributes to insulin mediated glucose uptake in morbidly obese subjects

Abstract

Keywords

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