Fas-FasL in Hashimoto's thyroiditis

Ruggero De Maria Marchiano, Giorgio Stassi, Ann Zeuner, Diana Di Liberto, Matilde Todaro, Lucia Ricci-Vitiani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

31 Citazioni (Scopus)

Abstract

Hashimoto's thyroiditis is a common chronic autoimmune disease characterized by the loss of thyroid follicular cells (thyrocytes) that are gradually replaced by lymphocytic infiltration and diffuse fibrosis. These morphological findings suggested that autoreactive T-cell clones were responsible for thyrocyte destruction and hypothyroidism through effector-target cytotoxic recognition. Later, autonomous interaction between thyrocyte Fas and FasL has been proposed as a major mechanism of thyrocyte depletion in Hashimoto's thyroiditis. Here, we analyze the possible role of Fas and FasL in the pathogenesis of Hashimoto's thyroiditis. We suggest that the Fas-FasL system dictates the outcome of the autoimmune response by acting on both immune and target cells.
Lingua originaleEnglish
pagine (da-a)19-23
Numero di pagine5
RivistaJournal of Clinical Immunology
Volume21
Stato di pubblicazionePubblicato - 2001

Keywords

  • CD95/APO-1
  • apoptosis
  • death receptors
  • thyroid autoimmunity

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