Failure of immunoglobulins to prevent neonatal thrombocytopenia in mothers with immunothrombocytopenic purpura

Antonio Alberto Zuppa, Assunta Tornesello, R. Mastrangelo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

We report the case of a full-term (gestational age: 39 weeks) female newborn of a mother affected by immunothrombocytopenic purpura, treated with a high total dose (2 g/kg) of intravenous IgG, administered over a 3-day period starting 3 days before delivery. Infant platelet count at birth was 20,000/mm3 and she showed a great number of petechiae on the first day of life. After a random donor platelet transfusion and treatment with intravenous high-dose IgG (400 mg/kg for 5 days), platelet count began to increase. We conclude that exogenous IgG, even at high concentrations, apparently does not significantly cross the placenta, despite adequate maternal blood levels.
Lingua originaleEnglish
pagine (da-a)450-452
Numero di pagine3
RivistaBIOLOGY OF THE NEONATE
Volume67
Stato di pubblicazionePubblicato - 1995

Keywords

  • Autoimmune Diseases
  • Female
  • Fetal Diseases
  • Humans
  • Immunoglobulin G
  • Infant, Newborn
  • Pregnancy
  • Pregnancy Complications, Hematologic
  • Purpura, Thrombocytopenic, Idiopathic
  • Treatment Failure

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